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2-Thiouracil is an established antithyroid pyrimidine analog and an extensively investigated agent for the early detection and targeting of metastatic melanotic melanoma. 2-thiouracil is effectively incorporated into the RNA and leads to alterations in the structure of the proteins synthesized. In addition, 2-Thiouracil is also a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerization.
| Molecular Weight | 128.15 |
| Formula | C4H4N2OS |
| CAS Number | 141-90-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NO Synthase Products |
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| Imperatorin
Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM. |
| Crocin-II
Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA. |
| Madecassic-acid
Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages. |
| Irisflorentin
Irisflorentin, a naturally occurring isoflavone, is an abundant active ingredient in Rhizoma Belamcandae. Irisflorentin significantly reduced the transcription and translation levels of iNOS and NO production. |
| Apioside
Apiin is one of the main components of Apium graveolens leaves and has anti-inflammatory properties. Apiin could inhibit nitrite (NO) production in vitro (IC50 = 0.08 mg/mL) and iNOS expression in LPS-activated J774.A1 cells (IC50 = 0.049 mg/mL). |
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