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2-ketoglutaric acid (alpha-ketoglutaric acid) is an intermediate produced by ATP or GTP in the Krebs cycle. 2-ketoglutaric acid also acts as the main carbon skeleton for nitrogen assimilation. 2-ketoglutaric acid is a reversible inhibitor of Tyrosinase (IC50=15 mM).
| Molecular Weight | 146.1 |
| Formula | C5H6O5 |
| CAS Number | 328-50-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Dunxin Shen, et al. Anal Biochem. Synthesis of α-Ketoglutaramic acid
[3] Zbigniew Zasłona, et al. Mol Cell. Cytokine-like Roles for Metabolites in Immunity
[4] Elisa Elena Baracco, et al. Aging (Albany NY). α-Ketoglutarate inhibits autophagy
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