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2-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM.
| Molecular Weight | 1187.3 |
| Formula | C66H68CaF2N4O12 |
| CAS Number | 265989-46-6 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HMG-CoA Reductase Products |
|---|
| Fluvastatin sodium
Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. |
| Rosuvastatin calcium
Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. |
| Mevastatin
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| Pravastatin sodium
Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| Clinofibrate
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
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