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2-Bromohexadecanoic acid (2-Bromopalmitic acid, 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-BP inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis. It has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation, and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS.
Cells. 2025 Mar 06;14(5):385.
Selective Azapeptide CD36 Ligand MPE-298 Regulates oxLDL-LOX-1-Mediated Inflammation and Mitochondrial Oxidative Stress in Macrophages
2-Bromohexadecanoic acid purchased from AbMole
| Molecular Weight | 335.32 |
| Formula | CH3(CH2)13CH(Br)CO2H |
| CAS Number | 18263-25-7 |
| Solubility (25°C) | DMSO > 60 mg/mL Methanol 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Han Yao, et al. Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours
[3] Yi Yang, et al. Palmitoylation stabilizes PD-L1 to promote breast tumor growth
[5] Kojiro Mukai, et al. Activation of STING requires palmitoylation at the Golgi
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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