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2-BFI hydrochloride

Cat. No. M8627

All AbMole products are for research use only, cannot be used for human consumption.

2-BFI hydrochloride Structure

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Quality Control & Documentation
Biological Activity

2-BFI hydrochloride is a high-affinity Imidzoline I2 receptor ligand (Ki = 9.8 nM). In an in vivo functional assay, 2-BFI produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Chemical Information
Molecular Weight 222.67
Formula C11H10N2O.HCl
CAS Number 89196-95-2
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Justin N Siemian, et al. Neuroanatomical characterization of imidazoline I 2 receptor agonist-induced antinociception

[2] Justin N Siemian, et al. The imidazoline I 2 receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain

[3] Justin N Siemian, et al. Antinociceptive Interactions between the Imidazoline I2 Receptor Agonist 2-BFI and Opioids in Rats: Role of Efficacy at the μ-Opioid Receptor

[4] Celia Garau, et al. Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain

[5] David A Thorn, et al. Effects of imidazoline I₂ receptor ligands on morphine- and tramadol-induced antinociception in rats

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Keywords: 2-BFI hydrochloride supplier, inhibitors, activators

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