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2,5-Dihydroxyacetophenone

Cat. No. M11181

All AbMole products are for research use only, cannot be used for human consumption.

2,5-Dihydroxyacetophenone Structure
Synonym:

DHAP, 2-Acetylhydroquinone, Quinacetophenone

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100mg USD 53 In stock
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Biological Activity

2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers used in food flavoring. 2',5'-Dihydroxyacetophenone significantly inhibits the production of NO by inhibiting the expression of iNOS. 2',5'-Dihydroxyacetophenone significantly reduces the expression levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.

Chemical Information
Molecular Weight 152.15
Formula C8H8O3
CAS Number 490-78-8
Solubility (25°C) DMSO ≥ 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aysha Siddiqa, et al. J Biomol Struct Dyn. Synthesis, antioxidant, in silico and computational investigation of 2,5-dihydroxyacetophenone derived chloro-substituted hydroxychalcones, hydroxyflavanones and hydroxyflavindogenides

[2] Jenny Schrter, et al. Anal Bioanal Chem. The combination of 2,5-dihydroxybenzoic acid and 2,5-dihydroxyacetophenone matrices for unequivocal assignment of phosphatidylethanolamine species in complex mixtures

[3] Jeong-Hyeon Ko, et al. Molecules. 2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway

[4] Yunkyung Han, et al. J Med Food. 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages

[5] Yusuke Morisawa, et al. J Phys Chem A. Photodissociation dynamics of 2,5-dihydroxyacetophenone

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Keywords: 2,5-Dihydroxyacetophenone , DHAP, 2-Acetylhydroquinone, Quinacetophenone supplier, ERK, inhibitors, activators

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