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2′,5′-Dideoxyadenosine is a cell-permeable adenylyl cyclase inhibitor, IC50 = 2.7 μM in detergent-dispersed rat brain preparations. 2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).
| Molecular Weight | 235.24 |
| Formula | C10H13N5O2 |
| CAS Number | 6698-26-6 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Adenylate Cyclase Products |
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| Forskolin
Forskolin is a diterpenoid natural product extracted from the hairy throat sphagnum flower (Coleus forskohlii), and is also a eukaryotic adenylate cyclase (AC) activator, which can increase cAMP levels. In addition, Forskolin can be used as a substitute for Oct4 in the induction and maintenance of pluripotent stem cells in mice and promotes osteoblast differentiation in vitro with potential anti-osteoporotic activity. |
| Bithionol
Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity. |
| SQ22536
SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets. |
| KH7
KH7 is a specific inhibitor of soluble adenylate cyclase (sAC) with IC50 values of 3-10 μM against recombinant sACt proteins (human and others) in cells. KH7 is also an inhibitor of cAMP. |
| ST034307
ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM, it has analgesic activity. |
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