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116-9e (MAL2-11B) is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. The Hsp40 family of co–chaperones binds to Hsp70 through a conserved J–domain. It is believed that 116-9e inhibits chaperone functions by preventing Hsp70–Hsp40 complex assembly.
116-9e (MAL2-11B) inhibited both TAg’s endogenous ATPase activity and the TAg-mediated activation of Hsp70.
| Molecular Weight | 512.6 |
| Formula | C31H32N2O5 |
| CAS Number | 831217-43-7 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA/RNA Synthesis Products |
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