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11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells.
11-Ketodihydrotestosterone (1-10 nM; 24 hours) induces significant cell proliferation in LNCaP and VCaP cells.
| Molecular Weight | 304.42 |
| Formula | C19H28O3 |
| CAS Number | 32694-37-4 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | Powder -20°C |
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