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1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM.
| Molecular Weight | 330.21 |
| Formula | C14H6N2O8 |
| CAS Number | 81-55-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 41.67 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | Powder -20°C |
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