| Cat.No. | Name | Information |
|---|---|---|
| M6494 | BCTC | BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
| M3422 | Capsaicin | Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. |
| M7698 | Capsazepine | Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin. |
| M10315 | MK6-83 | MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3). |
| M9962 | Nonivamide | Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. |
| M2960 | Probenecid | Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. |
| M7816 | GSK1016790A | GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells. |
| M1846 | SB-705498 | SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. |
| M7264 | SB 366791 | SB 366791 is a potent, selective, competitive TRPV1 antagonist. |
| M7387 | TCS 5861528 | TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. |
| M4122 | 8-Gingerol | 8-gingerol is derived from the rhizome of ginger (Z. officinale). It has oral activity and can activate TRPV1 with EC50 of 5.0 µM. 8-Gingerol inhibited COX-2 and h. pylori growth in vitro. |
| M3187 | Optovin | Optovin is a reversible photoactivated TRPA1 activator. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. |
| M2934 | Phenazopyridine hydrochloride | Phenazopyridine HCl is a competitive SARM1 inhibitor as well as a TRPM8 antagonist with an IC50 for SARM1 inhibition of 145 μM. It has local anesthetic/analgesic activity and can be used in studies related to traumatic brain injury, peripheral neuropathy, and neurodegenerative diseases. |
| M2591 | Icilin | Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. |
| M2383 | AMG-517 | AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. |
| M2087 | HC-030031 | HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively). |
| M58669 | 4-ONE | 4-ONE is one of the major hemolytic decomposition products of lipid hydroperoxides. 4-ONE is a potent transient receptor potential ankyrin 1 (TRPA1) agonist. |
| M56582 | AM12 | AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM. |
| M56581 | AMG0347 | AMG0347 is a transient receptor potential type V1 receptor antagonist. |
| M56580 | JNc-440 | JNc-440 is a potent antihypertensive agent. |
| M56578 | (Rac)-AMG 628 | (Rac)-AMG 628 is the racemate of AMG 628, a potent TRPV1 antagonist with an IC50 of 3.7nM. |
| M56577 | Umbellulone | Umbellulone is an active constituent of the leaves of Umbellularia californica. |
| M56576 | TRPV3 antagonist 74a | TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. |
| M52704 | N-Oleoyl glutamine | N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). |
| M52703 | N-Oleoyl valine | N-Oleoyl valine is a N-acyl valine compound that acts as a TRPV3 receptor antagonist. |
| M52701 | SOR-C13 | SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. |
| M44794 | beta-Eudesmol | Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1. |
| M43953 | GFB-887 | GFB-887 is an inhibitor of transient receptor potential channels 4 and 5 (TRPC4/5) and can be used in studies related to anxiety disorders. |
| M43944 | Tivanisiran | Tivanisiran is an siRNA that silences TRPV1 mRNA and can be used in studies related to dry eye. |
| M42267 | MK-2295 | MK-2295 (NGD-8243) is a TRPV1 antagonist. |
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