| Cat.No. | Name | Information |
|---|---|---|
| M6494 | BCTC | BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
| M3422 | Capsaicin | Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. |
| M7698 | Capsazepine | Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin. |
| M10315 | MK6-83 | MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3). |
| M9962 | Nonivamide | Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. |
| M2960 | Probenecid | Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. |
| M7816 | GSK1016790A | GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells. |
| M1846 | SB-705498 | SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. |
| M7264 | SB 366791 | SB 366791 is a potent, selective, competitive TRPV1 antagonist. |
| M7387 | TCS 5861528 | TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. |
| M7975 | Olvanil | Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM. |
| M7836 | Hyperforin | Hyperforin is a transient receptor typical 6 (TRPC6) channel activator that regulates Ca2+ levels by activating Ca2+-transducing non-selective typical TRPC6 channels, with antidepressant and antitumor activities. In addition, Hyperforin modulates IL-17α secretion from γδ T cells and ameliorates Imiquimod-induced skin inflammation in psoriasis-like mice. Hyperforin acts as a potent activator of PXR, leading to increased expression of target genes. |
| M7375 | TC-I 2000 | TC-I 2000 is a tRPM8 blocker. |
| M7303 | SKF 96365 hydrochloride | SKF-96365 hydrochloride is a potent TRP channel blocker and SOCE (store-operated Ca2+ entry) inhibitor. It also induces cell cycle arrest and apoptosis in colorectal cancer cells. |
| M7265 | SB 452533 | SB 452533 is a potent TRPV1 receptor antagonist. |
| M7216 | RQ 00203078 | RQ 00203078 is a potent and selective TRPM8 antagonist; orally active. |
| M7199 | RN 1734 | RN 1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). |
| M7013 | Naltriben mesylate | Naltriben mesylate is a potent and selective δ2-opioid receptor antagonist and a TRPM7 activator. Naltriben mesylate shows Ki values of 0.013 nM, 19 nM and 152 nM for δ, μ and κ receptors, respectively. |
| M6983 | ML SA1 | ML SA1 is a activator of TRPML channels. |
| M6741 | Gadolinium chloride | Gadolinium chloride is a stretch-activated calcium channel blocker; calcium-sensing receptor agonist. |
| M6705 | EIPA | EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). |
| M6605 | CIM0216 | CIM0216 is a potent and selective TRPM3 agonist. CIM0216 exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. CIM0216 acts in a TRPM3-dependent manner to induce pain and evoke neuropeptide release from sensory nerve terminals in vitro. |
| M6470 | ASP7663 | ASP7663 is an orally active and selective TRPA1 agonist. |
| M6441 | AMTB hydrochloride | AMTB hydrochloride is a tRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23). |
| M6437 | AMG 9810 | AMG 9810 is a potent and selective, competitive antagonist of TRPV1. |
| M6380 | A-967079 | A-967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). |
| M6373 | A 784168 | A 784168 is a potent and selective TRPV1 antagonist. |
| M6250 | AM-0902 | AM-0902 is a potent, selective antagonist of TRPA1 with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively. |
| M5349 | (+)-Camphor | Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3. |
| M4513 | Dihydrocapsaicin | Dihydrocapsaicin is a natural capsaicin that is a selective TRPV1 agonist and increases P-Akt levels. Dihydrocapsaicin can enhance hypothermic induced neuroprotection. |
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