| Cat.No. | Name | Information |
|---|---|---|
| M10315 | MK6-83 | MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3). |
| M9962 | Nonivamide | Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. |
| M7816 | GSK1016790A | GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells. |
| M7698 | Capsazepine | Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin. |
| M7387 | TCS 5861528 | TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. |
| M7264 | SB 366791 | SB 366791 is a potent, selective, competitive TRPV1 antagonist. |
| M6494 | BCTC | BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
| M3422 | Capsaicin | Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. |
| M2960 | Probenecid | Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. |
| M1846 | SB-705498 | SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. |
| M66247 | Farnesyl pyrophosphate triammonium | Farnesyl pyrophosphate triammonium is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate triammonium is a metabolic intermediate in the mevalonate (MVA) pathway. Farnesyl pyrophosphate triammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. |
| M65737 | N-Arachidonoyl Taurine | N-Arachidonoyl Taurine is an activator of the transient receptor potential vanilloid TRPV1 and TRPV4, with EC50 values of 28 μM and 21 μM, respectively. |
| M59390 | (E)-N-(p-Amylcinnamoyl)anthranilic acid | N-(p-Amylcinnamoyl)anthranilic acid is a broad spectrum PLA2 inhibitor and TRP channel blocker. N-(p-Amylcinnamoyl)anthranilic acid (ACA) functions as a broad spectrum phospholipase A2 inhibitor and blocks transient receptor potential (TRP) channels. It inhibits calcium activated chloride current in cardiac ventricular myocytes. N-(p-Amylcinnamoyl)anthranilic acid has been used as a transient receptor potential cation channel subfamily M member 2 (TRPM2) inhibitor, in studying its role in regulating the production of reactive oxygen species (ROS). |
| M58999 | PF-04745637 | PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1. |
| M58991 | Phenazopyridine | Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine can promote neuronal differentiation and it can also be used in the research of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases. |
| M58386 | Moringin | Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. |
| M58326 | (S)-ABT-102 | (S)-ABT-102 is a potent TRPV1 antagonist, with an IC50 of 123 nM. (S)-ABT-102 can block the activation of TRPV1 by capsaicin. |
| M58325 | Oleoyl Serotonin | Oleoyl Serotonin is a TRPV1 antagonist with IC50 value of 2.57 μM for human TRPV1. |
| M58324 | ABT-102 | ABT-102 (CHEMBL398338) is a potent and highly selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. |
| M58323 | MK-2295 | MK-2295 (TRPV1 antagonist 5) is a potent TRPV1 antagonist. MK-2295 can be used for the research of chronic pain. |
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