| Cat.No. | Name | Information |
|---|---|---|
| M4798 | Tunicamycin | Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin can cause the accumulation of unfolded proteins within the endoplasmic reticulum (ER) and induce ER stress, leading to impaired DNA synthesis and G1 phase cell cycle arrest. |
| M29537 | LAS17 | LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione S-Transferase Pi (GSTP1) . LAS17 inhibits GSTP1 activity with an IC50 of 0.5 µM. |
| M29305 | FR-190809 | FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM. |
| M29127 | AZD9898 | AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma. |
| M28998 | Pactimibe | Pactimibe (CS-505) free base is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505) free base inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively. Pactimibe (CS-505) free base noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. |
| M28440 | BMS-963272 | BMS-963272 is a potent, selective MGAT2 inhibitor (IC50 = 7.1 nM) for the research of metabolic disorders. |
| M28218 | CP-113818 | CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease. |
| M28200 | Nevanimibe | Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer. |
| M28148 | Lecimibide | Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research. |
| M19273 | Curzerene | Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis. |
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