| Cat.No. | Name | Information |
|---|---|---|
| M4798 | Tunicamycin | Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin can cause the accumulation of unfolded proteins within the endoplasmic reticulum (ER) and induce ER stress, leading to impaired DNA synthesis and G1 phase cell cycle arrest. |
| M39049 | Enniatin B1 | Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 can cross the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation. |
| M30357 | Pactimibe sulfate | Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. |
| M27868 | Fumonisin B1 | Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin. |
| M25436 | EGR240 | ERG240 is a selective inhibitor of branched-chain aminotransferase 1 (BCAT1) with an IC50 of 0.1-1nM. ERG240 leads to decreased oxygen consumption and glycolysis through the down regulation of IRG1 expression, which leads to decrease itaconate production in human macrophages. |
| M21597 | Beauvericin | Beauvericin is a fusarium toxin. It has a wide range of antifungal, antibacterial, protozoal and insecticidal activities, exhibits ionic properties and inhibits acyl-coenzyme: cholesterol acyltransferase activity; Apoptosis was induced by increasing intracellular calcium levels. |
| M20843 | NNMTi | NNMTi (Compound 1k, NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.2 μM. |
| M16083 | Seneciphylline | Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities. |
| M14767 | SHIN1 | SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. |
| M14294 | OSMI-4 | OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells. |
| M11323 | 10,12-Tricosadiynoic acid | Tricosadiynoic acid, 10,12-Tricosadiynoic acid, is A highly specific, selective, high-affinity acyl-coa oxidase-1 (ACOX1) inhibitor with oral activity. Tricosadiynoic acid can improve mitochondrial lipid and ROS metabolism and can be used to study metabolic diseases caused by high fat diet or obesity. |
| M10176 | 3-Methoxybenzamide | 3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT). |
| M10100 | Opicapone | Opicapone, also known as BIA 9-1067, is a novel potent and selective catechol-O-methyltransferase inhibitor (COMT inhibitor). |
| M9349 | Adenosine Dialdehyde | Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM. |
| M9234 | Hecogenin | Hecogenin is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. |
| M8728 | ESI-05 | Esi-05 (NSC 116966) is a camp-specific direct activated exchange protein 2 (EPAC2) antagonist with an IC50 value of 0.4 µM that inhibits camp-induced EPAC2 activation and EAPC2-mediated Rap1 activation. |
| M8694 | K-604 dihydrochloride | K-604 dihydrochloride inhibits against acyl-coenzyme A (acyl-CoA):cholesterol O-acyltransferase-1 (ACAT1, SOAT1) activitiy in a selective (IC50 = 450 nM vs. 102.85 μ M against human ACAT1 and ACAT2, respectively) and acyl-CoA-competitive (Ki = 378 nM against oleoyl-coA) manner. |
| M8587 | OSMI-1 | OSMI-1 is a cell permeable inhibitor of OGT (O-GlcNAc transferase) with an IC50 value of 2.7 μM. |
| M8202 | Sandoz 58-035 | Sandoz 58-035 is a cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture. Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages. |
| M3078 | Tolcapone | Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM. |
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