| Cat.No. | Name | Information |
|---|---|---|
| M1962 | Lenalidomide | Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
| M4240 | Shikonin | Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. |
| M4022 | Hypaconitine | Hypaconitine is a highly toxic natural active ingredient isolated from aconitum species, which is widely used to study rheumatism. |
| M4021 | Mesaconitine | Mesaconitine is the main active ingredient of Aconitum and has many pharmaceutical effects. |
| M1545 | Infliximab | Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that blocks TNF-α interaction with TNF-α receptor 1 (TNFR1) and TNFR2. For the treatment of autoimmune diseases. Infliximab is available in BALB/ C or C57/Bl6 mice. |
| M58439 | Ozekibart | Ozekibart is an anti-TNFRSF10B monoclonal antibody. |
| M55908 | TAPI-0 | TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. |
| M55357 | BMS-566394 | BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE). |
| M55255 | APVO603 | APVO603 is a dual agonist bispecific antibody employing a novel mechanism of action to simultaneously target 4-1BB (CD137) and OX40 (CD134), both members of the TNF-receptor family. |
| M55254 | STAR-0310 | STAR-0310 is a novel OX40 antagonistic monoclonal antibody which has a potential best-in-class profile with a high affinity, potential for favorable safety and tolerability profile with low T cell depletion from ADCC or possible on-target cellular toxicity. |
| M55252 | FS120 | FS120 is a first-in-class dual-agonist tetravalent bispecific antibody targeting CD137 (4-1BB, TNFRSF9) and OX40 (CD134, TNFRSF4). FS120 has the potential to show activity in "cold" tumors and improve outcomes of existing immunotherapies by simultaneously agonizing CD137 and OX40. |
| M55251 | ATOR-1015 | ATOR-1015 is a human CTLA-4 x OX40 targeting IgG1 bispecific antibody with enhanced immune activation and tumor-directed activity for improved efficacy and reduced toxicity. ATOR-1015 induces T-cell activation and Treg depletion in vitro. |
| M55250 | YH002 | YH002 is a recombinant anti-OX40 (CD134, TNFRSF4) humanized IgG1 agonistic antibody. |
| M55249 | HFB 3010 | HFB 3010 (HFB 301001) is a novel second-generation fully human IgG1 class OX40 agonistic monoclonal antibody. |
| M55246 | MEDI6469 | MEDI6469 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response. |
| M55241 | INCAGN-1949 | INCAGN-1949 is a novel fully human IgG1 monoclonal anti-OX40 antibody with the potential to enhance tumor-specific T-cell responsiveness, while selectively depleting intratumoral regulatory T cells. Commensurate with its human IgG1 Fc region, INCAGN-1949 can effectively co-engage activating Fcγ receptors on immune effector cells, including natural killer cells and macrophages. |
| M55240 | SAR-442970 | SAR 442970 is an anti tumour necrosis factor alpha (TNFα) and OX40 ligand (OX40L) molecule. |
| M55239 | IMG-007 | IMG-007 is a novel humanized IgG1 mAb that specifically binds to the OX40 receptor and potently blocks the signaling between OX40 and its ligand. IMG-007 has been engineered to have an extended half-life to allow less frequent dosing and a silenced antibody-dependent cell-mediated cytotoxicity (ADCC) function to reduce safety risks. |
| M55238 | BAT6026 | BAT6026 is a novel human anti-OX40 antibody with enhanced antibody dependent cellular cytotoxicity (ADCC) via fucose deletion to strengthen its Treg depletion activity. BAT6026 activated T cells more effectively when clustered by FcγRs engagement and stimulated SEB-pretreated PBMCs to secrete IL-2 cytokines in vitro. |
| M55237 | BGB-A445 | BGB-A445 is a humanized anti-OX40 IgG1 monoclonal agonistic antibody with Fc activity that binds with high specificity and affinity to the extracellular domain of human OX40 and induces an anti-tumor immune response. |
| M54557 | Chilob7/4 | Chilob7/4 is a chimeric agonist anti-CD40 IgG1 antibody that can be used for tumor-related studies. |
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