| Cat.No. | Name | Information |
|---|---|---|
| M1962 | Lenalidomide | Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
| M24893 | Mitazalimab | Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment. |
| M24765 | Vonlerolizumab | Vonlerolizumab (MOXR 0916) is a humanized IgG agonistic monoclonal OX40-specific antibody. Vonlerolizumab can be used for the research of cancer. |
| M18028 | 8-Epi-Loganic acid-6'-O-β-D-glucoside | 8-Epi-Loganic acid-6'-O-β-D-glucoside |
| M13561 | C25-140 | C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity. |
| M13560 | AX-024 | AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. |
| M11179 | CPI-1189 | CPI-1189 (REN 1654, REN 1189) is an inhibitor of tumor necrosis factor (TNF) alpha. CPI-1189 inhibits the phosphorylation activation of protein kinase activated by p38 mitogens in cells and plays a neuroprotective role. |
| M10667 | UTL-5g | UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. |
| M10643 | Benpyrine racemate | Benpyrine racemate ((Rac)-Benpyrine) is a racemate of Benpyrine, Benpyrine racemate ((Rac)-Benpyrine) is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research. |
| M10324 | Cynaropicrin | Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release and the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling. |
| M9710 | Roquinimex | Roquinimex (LS2616; FCF89) is a quinoline-3-carboxamide with potential antineoplastic activity, which increases NK cell activity and macrophage cytotoxicity. |
| M8516 | R-7050 | R-7050 is a cell-permeable TNF-α receptor antagonist that blocks TNF-α-induced binding of TNF-αRI with TNFαR-associated death domain protein and receptor interacting protein 1, blocking internalization of the TNFα-TNFαR complex. |
| M7532 | KR-33493 | KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1). |
| M6222 | Adalimumab | Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD. |
| M5732 | Lenalidomide hemihydrate | Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM. |
| M5272 | Bioymifi | Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis. |
| M4795 | Homoplantaginin | Homoplantaginin is a flavonoid from Traditional Chinese medicine Salvia plebeia with anti-inflammatory and antioxidant activities. |
| M4740 | Corilagin | Corilagin is an inhibitor of TNF-α, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. |
| M4737 | Geraniin | Geraniin is a TNF-α releasing inhibitor with an IC50 of 43 μM, it has numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities. |
| M4502 | Mulberroside A | Mulberroside A is one of the main bioactive components in Mulberry (Morus alba L.). Mulberroside A reduced the expression of TNF-α, IL-1β and IL-6, inhibited the activation of NALP3, Caspase-1 and NF-κB, and phosphorylated ERK, JNK and P38. Mulberroside A has anti-inflammatory and anti-apoptotic effects. |
| M4378 | Forsythoside B | Forsythoside B inhibits TNF-alpha, IL-6, IκB and modulate NF-κB. |
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