| Cat.No. | Name | Information |
|---|---|---|
| M10459 | MSA-2 | MSA-2 is an orally available non-nucleotide STING agonist with antitumor activity. MSA-2 shows EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. |
| M10126 | H-151 | H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation. |
| M9923 | SR-717 | SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. |
| M9893 | C-176 | C-176 is a potent, selective and blood-brain barrier permeable inhibitor of STING. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING. |
| M58676 | c-di-AMP disodium | c-di-AMP disodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP disodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. |
| M56404 | SN-011 | SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. |
| M45401 | Vomicine | Vomicine is an alkaloid with antidiabetic activity. Vomicine modulates cGAS-STING-TBK1 signaling pathway, and exhibits anti-inflammatory activity. |
| M21652 | SN-001 | SN-001 is a STING inhibitor with an IC50 of 3.82 μM. SN-001 targets the cyclic dinucleotide binding pocket of human STING. |
| M21115 | E7766 diammonium salt | E7766 diammonium salt is a macrocyclic bridging STING agonist with a Kd of 40 nM. It has potent pan-genotypic and antitumor activity. |
| M20842 | C-171 | C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING. |
| M14125 | STING-IN-2 | STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research. |
| M14124 | STING agonist-3 | STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. |
| M14123 | diABZI | diABZI (Diamidobenzimidazole STING Agonist-1) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
| M14121 | Cyclic-di-GMP | Cyclic-di-GMP (c-di-GMP) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species. |
| M14120 | cGAMP disodium | cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. |
| M14119 | cGAMP diammonium | cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. |
| M11332 | diABZI trihydrochloride | diABZI (STING agonist-1) trihydrochloride is a selective agonist of interferon gene-stimulated receptor (STING), with EC50 scores of 130 nM and 186 nM in mice and humans, respectively. |
| M10299 | c-di-AMP | c-di-AMP (Cyclic diadenylate) is a STING agonist, it binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. |
| M10125 | C-178 | C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation. |
| M9729 | diABZI (tautomerism) | diABZI (STING agonist 1; Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
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