| Cat.No. | Name | Information |
|---|---|---|
| M2331 | PP2 | PP2 (AGL 1879) is a selective inhibitor of Src-family tyrosine kinases with >10,000-fold selectivity over ZAP-70 and JAK2. |
| M1701 | Dasatinib | Dasatinib (BMS-354825) is a small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively. |
| M1648 | AP24534 | Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor of BCR-ABL, PDGFRα, c-Src, c-Kit, FGFR and VEGFR. |
| M1799 | Imatinib Mesylate | Imatinib Mesylate is a Bcr-Abl tyrosine kinase inhibitor, with IC50 values of 2.9 and 3.9 μM for the inhibition of T-cell proliferation stimulated by PHA and DCs respectively. |
| M1685 | Bosutinib | Bosutinib (SKI-606) is a novel Bcr-Abl inhibitor with IC50 values of 0.1 to 0.3 umol/L. |
| M3194 | Nocodazole | Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. |
| M1912 | Nilotinib | Nilotinib (AMN107) is a small molecule Bcr-Abl kinase inhibitor with IC50 less than 30 nM. |
| M14910 | A-770041 | A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. |
| M9798 | 1NM-PP1 | 1NM-PP1 is a cell-permeable and potent Src family kinases inhibitor with IC50 values of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. |
| M9664 | TL02-59 | TL02-59 is a selective, orally active Src-family kinase Fgr inhibitor with IC50 of 0.03 nM, it also inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. |
| M9548 | CZC-8004 | CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase. |
| M9493 | Flumatinib mesylate | Flumatinib mesylate is a selective inhibitor of BCR-ABL/PDGFR/c-Kit with IC50s of 1.2 nM, 307.6 nM and 2662 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model. |
| M9259 | Asciminib | Asciminib, also known as ABL001, is a potent allosteric inhibitor of BCR-ABL, with a Kd value of 0.5-0.8 nM. |
| M9067 | TG-100572 hydrochloride | TG-100572 hydrochloride is a potent and selective multi-targeted VEGFR2/Src kinase inhibitor. |
| M9009 | Ponatinib hydrochloride | Ponatinib hydrochloride is a potent, orally available multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively. |
| M8311 | MLR-1023 | MLR-1023 (Tolimidone) is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase that produces lasting glucose lowering, reduces HbA1c levels, and preserves pancreatic β-cells in db/db mice. |
| M8255 | DPH | DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation. |
| M8160 | Src Inhibitor-1 | Src interactivator-1 is a highly selective, ATP-competitive, two-site Src tyrosine kinase Inhibitor with IC50 values of 44 nM and 88 nM against Src and Lck, respectively. Src interactivator-1 also inhibits Csk and Yes. |
| M7569 | AMG-47a | AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. |
| M6367 | A 419259 trihydrochloride | A 419259 trihydrochloride is a inhibitor of Src family kinases. |
| M6305 | Olverembatinib | Olverembatinib is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. |
| M5916 | Radotinib | Radotinib is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia. |
| M5553 | Dasatinib Monohydrate | Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively. |
| M5552 | Dasatinib HCl | Dasatinib(BMS-354825) hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of ＜1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. |
| M5330 | Nilotinib (monohydrochloride monohydrate) | Nilotinib (AMN-107) is a Bcr-Abl inhibitor with IC50 less than 30 nM. |
| M5190 | GNF-7 | GNF-7 is the first type II inhibitors capable of inhibiting T315I to be described and will serve as a valuable lead to design next generation Bcr-Abl kinase inhibitors. |
| M4843 | SU6656 | SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. |
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