| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M58140 | HwTx-IV | Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule. |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M30584 | Nicainoprol | Nicainoprol is a fast-sodium-channel blocking agent, which is a potent antiarrhythmic agent. |
| M29882 | NS383 | NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits. |
| M28858 | GX-201 | GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7. |
| M28760 | AMG8379 | AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM. |
| M28554 | S-8921 | S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. |
| M28446 | AM-2099 | AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16 μM for human Nav1.7. |
| M28426 | GX-674 | GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 of 0.1 nM at -40 mV. |
| M28397 | (+)-SJ733 | (+)-SJ733 is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4. |
| M28305 | PF-05241328 | PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM. |
| M28267 | AZD-3161 | AZD-3161 is a potent and selective blocker of NaV1.7 channel, with a pIC50 of 7.1. AZD-3161 can be used for the research of neuropathic and inflammatory pain. |
| M28226 | Clathrodin | Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance. |
| M28082 | Funapide | Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor. |
| M28007 | PF-05198007 | PF-05198007 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. |
| M28006 | PF-05186462 | PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain. |
| M27998 | Bliretrigine | Bliretrigine is a sodium channel blocker. Bliretrigine has the effect of relieving pain. |
| M27938 | QAQ | QAQ dichloride dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain. |
| M22302 | Evenamide | Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker with Ki value of 0.4 µM. |
| M21271 | DS-1971a | DS-1971a is a potent, homozygous form-selective aryl sulfonamide NaV1.7 inhibitor for the treatment of neuropathic pain. |
| M21188 | NBI-921352 | Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha blocker. |
| M21126 | GDC-0310 | GDC-0310 is a selective Nav1.7 acyl sulfonamide inhibitor with an IC50 value of 0.6 nM for hNav1.7. It is an oral primary clinical candidate for the study of pain. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
