| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M58140 | HwTx-IV | Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule. |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M7463 | Veratridine | Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. |
| M7288 | SEA 0400 | SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. |
| M7180 | QX 314 bromide | QX 314 bromide is a na+ channel blocker. |
| M6755 | GMQ hydrochloride | GMQ hydrochloride is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation. |
| M6498 | Benzamil | Benzamil is a nCX inhibitor, Deg/ENaC channel blocker; amiloride derivative. |
| M6342 | 4-Chlorophenylguanidine hydrochloride | 4-Chlorophenylguanidine hydrochloride is a urokinase inhibitor. |
| M6085 | Raxatrigine | Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. |
| M6068 | Zonisamide | Zonisamide is an fDA-approved antiepileptic compound that blocks voltage-dependent sodium (+) and T-type calcium channels. |
| M6054 | Vinpocetine | Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. |
| M5943 | Rufinamide | Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication. |
| M5904 | Proparacaine HCl | Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. |
| M5876 | Phenytoin Sodium | Phenytoin Sodium is a potent Voltage-gated Na+ channels (VGSCs) blocker. |
| M5875 | Phenytoin | Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin reduces breast tumour growth and metastasis in mice, and it also has antiepileptic activity. Phenytoin has been shown to activate PXR and subsequently influence the expression of PXR target genes. |
| M5699 | Ibutilide fumarate | Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. |
| M4765 | Oleandrin | Oleandrin (PBI-05204) inhibited Na+, K+ -atPase activity with IC50 of 620 nM. |
| M4339 | Bufalin | Bufalin is a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM respectively, it has anti-cancer activity. |
| M4148 | Dimethyl-lithospermate-B | Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows sodium current (INa) inactivation, resulting in an early increase in inward current of the action potential (AP). |
| M4068 | Ginsenoside-Rg3 | 20(S)-Ginsenoside Rg3 is the main ingredient of red ginseng. 20(S) -ginsenoside Rg3 inhibited Na+ and hKv1.4 channels with IC50 of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S) -ginsenoside Rg3 also inhibited Aβ, NF-κB activity and COX-2 expression. |
| M4020 | Bulleyaconi-cine-A | Bulleyaconitine A, A compound isolated from aconite, has anti-inflammatory activity and can also be used in pain relief studies. |
| M3987 | Ginsenoside Rb1 | Ginsenoside Rb1 is an ingredient in the Chinese medicine Panax ginseng. Ginsenoside inhibition Na, K-ATPase++ activityIC50 6.3±1.0 μM. Ginsenoside Rb1 also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. |
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