| Cat.No. | Name | Information |
|---|---|---|
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M3417 | Clozapine | Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| M2821 | Lorcaserin hydrochloride | Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| M5656 | Fluoxetine hydrochloride | Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| M14577 | Fluoxetine | Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. |
| M3659 | Pimavanserin | Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively. |
| M3006 | Sertraline hydrochloride | Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM. |
| M7684 | Clozapine N-oxide | Clozapine N-oxide (CNO) is a 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC. |
| M59061 | PF-03382792 | PF-03382792 is a potent 5-HT4 partial agonist with a Ki of 2.7 nM and an EC50 of 0.9 nM for 5-HT4d. PF-03382792 can penetrate the brain. |
| M3772 | SB242084 | SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. |
| M9252 | YL-0919 | YL-0919 is a novel 5-HT1A receptor agonist and selective serotonin reuptake inhibitor. YL-0919 inhibits the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells with IC50 values of 1.78±0.34 nM and 1.93±0.18 nM, respectively. |
| M9025 | Idalopirdine hydrochloride | Idalopirdine hydrochloride is a potent and selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. |
| M9011 | PRX-08066 | PRX-08066 is a a novel 5-hydroxytryptamine receptor 2B antagonist with IC50 of 3.4 nM. |
| M8955 | MIN-101 | MIN-101 (Roluperidone) is a novel compound with affinities for 5-HT2A and sigma-2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively. |
| M8942 | GSK163090 | GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist. |
| M8932 | Eptapirone | Eptapirone (F11440) is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. |
| M8900 | TG6-10-1 | TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. |
| M8864 | Zotepine | Zotepine is a potent 5-HT2A, 5-HT2C, histamine H1, α1-adrenergic, and dopamine D2 receptor antagonist with Kd values of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. |
| M8861 | Xaliproden hydrochloride | 5-HT1A serotonin receptor agonist; neuroprotectant. |
| M8576 | LP-211 | LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. |
| M8566 | Eltoprazine hydrochloride | Eltoprazine hyrochloride is a serotonin 5-HT1A/1B receptor agonist that has been shown to reduce L-DOPA-induced dyskinesias in in experimental models of Parkinson′s Disease and in human patients. |
| M8503 | SB-207266 | SB-207266 is a potent, selective, orally active and long-acting 5-HT4 antagonist in vivo. |
| M8091 | PF-04995274 | PF-04995274 is a potent partial agonist of serotonin 5HT4 receptor with Ki = 0. |
| M7924 | Metergoline | Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. |
| M7799 | Norfluoxetine hydrochloride | Norfluoxetine hydrochloride is an active N-demethylated fluoxetine metabolite, Norfluoxetine hydrochloride is more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days. |
| M7763 | Diacylglycerol Kinase Inhibitor I | Diacylglycerol Kinase Inhibitor I (R 59-022) is an inhibitor of Diacylglycerol Kinase (DGK) and 5-HT Receptor with an IC50 value of 2.8 µM for DGK and inhibits the phosphorylation of OAG to OAPA.In addition, Diacylglycerol Kinase Inhibitor I also activates protein kinase C (PKC). In addition, Diacylglycerol Kinase Kinase Inhibitor I also activates protein kinase C (PKC). |
| M7259 | SB 228357 | SB 228357 is a 5-HT 2C/2B antagonist/inverse agonist. |
| M7248 | SB 200646 hydrochloride | SB 200646 hydrochloride is a 5-HT 2C/2B antagonist. |
| M7226 | RS 67333 hydrochloride | RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. |
| M6984 | MM 77 dihydrochloride | MM 77 dihydrochloride is a 5-HT 1A (postsynaptic) antagonist. |
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