| Cat.No. | Name | Information |
|---|---|---|
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M3417 | Clozapine | Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| M2821 | Lorcaserin hydrochloride | Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| M5656 | Fluoxetine hydrochloride | Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| M14577 | Fluoxetine | Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. |
| M3659 | Pimavanserin | Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively. |
| M3006 | Sertraline hydrochloride | Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM. |
| M7684 | Clozapine N-oxide | Clozapine N-oxide (CNO) is a 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC. |
| M59061 | PF-03382792 | PF-03382792 is a potent 5-HT4 partial agonist with a Ki of 2.7 nM and an EC50 of 0.9 nM for 5-HT4d. PF-03382792 can penetrate the brain. |
| M3772 | SB242084 | SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. |
| M2155 | (1S-cis)-Milnacipran Hydrochloride | (1S-cis)-Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. |
| M2146 | Prucalopride | Prucalopride is a potent, selective and specific serotonin 5-HT4 receptor agonist with enterokinetic properties. |
| M2134 | Vortioxetine hydrobromide | Vortioxetine hydrobromide (Lu AA21004) is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (5-HTT) inhibitor in vitro. |
| M1930 | Granisetron hydrochloride | Granisetron hydrochloride is a potent and selective 5-HT3 receptor antagonist that possesses potent antiemetic activity. |
| M1574 | Iloperidone | Iloperidone, a serotonin (5-HT2) receptor inhibitor, is used to study schizophrenia. |
| M1565 | Quetiapine sulfoxide | Quetiapine sulfoxide is a 5-HT receptor agonist with a pEC50 value of 4.77 for human 5-HT1A. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 value of 6.33 for human D2. |
| M1564 | Quetiapine Sulfone | Quetiapine Sulfone is a 5-HT receptor agonist with a pEC50 value of 4.77 for human 5-HT1A. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 value of 6.33 for human D2. |
| M1559 | Clomipramine Hydrochloride | Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
| M1454 | Buspirone | Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. |
| M58580 | Tegaserod | Tegaserod is an orally active serotonin receptor 4 (5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. |
| M56103 | AS19 | AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. |
| M56102 | CP94253 | CP94253 is a selective, orally active agonist for serotonin receptor 1B (5-HT1B), through competitive binding with iodocyanopindolol (ICP) to the 5-HT1 receptor. |
| M56101 | RS 39604 | RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. |
| M56100 | GR127935 | GR127935 is a selective 5-HT1D receptor antagonist. |
| M56098 | BRL-15572 | BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. |
| M56097 | SB 243213 | SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. |
| M56096 | BGC20-761 | BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). |
| M56095 | Ro60-0175 | Ro60-0175 is a potent and selective agonist of 5-HT2C receptor. |
| M56094 | GR 125743 | GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. |
| M56093 | SB-216641A | SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. |
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