| Cat.No. | Name | Information |
|---|---|---|
| M2562 | ZCL278 | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
| M6282 | NSC 23766 | NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. |
| M9356 | AMG-510 | AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor. |
| M9428 | MRTX849 (Adagrasib) | MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. |
| M8999 | CCG-1423 | CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling. |
| M49478 | RMC-8839 | RMC-8839 is an orally available, mutant-selective, direct inhibitor of KRAS G13C. |
| M49477 | YL-17231 | YL-17231 is a pan-KRAS mutant oral small molecule inhibitor in combination with the KRAS switch II pocket for studies related to KRAS mutant solid tumors. |
| M49368 | RM-032 | RM-032 is an orally active KRAS inhibitor that covalently binds to KRAS G12C and procyclin A to inhibit RAS pathway signaling and cell proliferation in KRAS G12C tumor cells. |
| M49367 | SML-8-73-1 | SML-8-73-1 is a GDP analog and also a KRAS inhibitor that irreversibly covalently binds to the GTPase active site of KRAS, and its binding rate to KRAS G12C was more than 95% in a 1 mmol/L GDP/GTP environment, and the IC 50 value for the inhibition of the proliferation of lung cancer cells H358 was 26.6 μmol/L . |
| M45215 | ABSK071 | ABSK071 is a novel KRAS G12C inhibitor with antitumor activity. |
| M45162 | BI 1823911 | BI 1823911 is a novel, highly selective, covalently irreversible oral small molecule inhibitor of KRASG12C. |
| M45161 | ARS-3248 | ARS-3248 is a novel KRAS G12C inhibitor. |
| M45160 | LY3499446 | LY3499446 is a KRAS G12C covalent inhibitor for studies related to non-small cell lung cancer (NSCLC). |
| M43844 | MK-1084 | MK-1084 is a KRAS G12C inhibitor that can be used in studies related to solid tumors. |
| M41938 | CFL-120 | CFL-120 is a potent KRasG12C inhibitor. |
| M41937 | CFL-137 | CFL-137 is a potent KRasG12C inhibitor. |
| M41936 | Oligomycin D | Oligomycin D (Rutamycin A) is an antibiotic. |
| M41935 | KRAS inhibitor-22 | KRAS inhibitor-22 is a potent inhibitor of K-Ras. |
| M41934 | pan-KRAS-IN-3 | pan-KRAS-IN-3 is a pan-KRAS inhibitor. |
| M41933 | KRASG12C IN-2 | KRASG12C IN-2 is an orally active KRASG12C inhibitor. |
| M41932 | Rac1-IN-3 | Rac1-IN-3 is a Rac1 inhibitor with an IC50 of 46.1 μM. |
| M41931 | PAT-IN-2 | PAT-IN-2 is a protein acyl transferases (PAT) inhibitor. |
| M41930 | PAT-IN-1 | PAT-IN-1 is a protein acyl transferases (PAT) inhibitor. |
| M41929 | RMC-4998 | RMC-4998 is a molecular glue compound with good antitumor activity. |
| M41928 | SCH54292 | SCH54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 μM. |
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