Pregnane X Receptor Pregnane X Receptor (PXR)

Agonist/Activator

Cat.No.	Name	Information
M21085	Pregnenolone 16α-carbonitrile	Pregnenolone 16α-carbonitrile is a derivative of pregnendione that functions as an agonist of the rodent pregnane X receptor (PXR). pregnenolone 16α-carbonitrile is a synthetic steroid that induces expression of cytochrome P450 3A. Pregnenolone 16α-carbonitrile exhibits greater tolerance to subsequent stress injury.
M14989	Citral	Citral is a monoterpene found in Cymbopogon citratus essential oil, with antihyperalgesic, anti-nociceptive and anti-inflammatory effects. Citral has been shown to activate PXR and induce its target genes. Citral is also a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines.
M7324	SR 12813	SR 12813 is an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR). SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM.