| Cat.No. | Name | Information |
|---|---|---|
| M6074 | AA26-9 | AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. |
| M4974 | GW4869 2HCl | GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is also an inhibitor of exosome biogenesis/release, followed by endotoxin (LPS) challenge. GW4869 could effectively inhibit the generation of exosomes in macrophages and in vivo. |
| M3969 | Polydatin | Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum, with biological properties, such as anti-inflammation, anti-oxidative and nephroprotective effects. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses. |
| M59310 | M-3M3FBS | M-3M3FBS is a potent phospholipase C (PLC) activator. M-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. M-3M3FBS induces monocytic leukemia cell apoptosis. |
| M56769 | Vinaxanthone | Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC50s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. |
| M52550 | Phospholipase A2 | Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA). |
| M49432 | Melittin | Melittin is a PLA2 activator that stimulates the activity of low molecular weight PLA2 without increasing the activity of high molecular weight PLA2. |
| M42574 | SB-435495 | SB-435495 is a potent, selective, reversible, non-covalent and orally active Lp-PLA2 inhibitor with an IC50 of 0.06 nM. |
| M29963 | DPTIP | DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM. |
| M28097 | BAPTA tetrasodium | BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators. |
| M21681 | Compound 48/80 trihydrochloride | Compound 48/80 trihydrochloride is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways. |
| M21360 | (E/Z)-Polydatin | (E/Z)-Polydatin (E/Z)-Piceid) is a single-crystal compound originally isolated from the roots and rhizomes of Echinacea purpurea with antiplatelet aggregation, anti-low density lipoprotein (LDL) oxidation, cardioprotective, anti-inflammatory and immunomodulatory properties. |
| M18276 | 1-Naphthaleneacetic acid | 1-Naphthaleneacetic acid is a auxin which can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM. |
| M14514 | N-(p-amylcinnamoyl) Anthranilic Acid | N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker. |
| M14513 | Melittin TFA | Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2. |
| M14512 | MAFP | MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase. |
| M14511 | LEI-401 | LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. |
| M14510 | D609 | D609 is a selective competitive inhibitor of phosphatidyl choline-specific phospholipase C (PC-PLC), with Ki of 6.4 μM. |
| M14509 | CAY10650 | CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion. |
| M14508 | 3-Nitrocoumarin | 3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor. |
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