| Cat.No. | Name | Information |
|---|---|---|
| M2849 | Microcystin-LR | Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| M6314 | SHP099 | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
| M7533 | SHP099 hydrochloride | SHP099 hydrochloride is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. |
| M14493 | MSI-1436 lactate | MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM). |
| M3837 | β-Glycerophosphate disodium salt hydrate | β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. |
| M20414 | PTP Inhibitor I | PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively. |
| M20410 | PTP Inhibitor II | PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM. |
| M19381 | Guaiacin | Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation. |
| M18562 | 4-Methylesculetin | 4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. |
| M14496 | SBI-425 | SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. |
| M14489 | DT-061 | DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. |
| M14487 | Calyculin A | Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively. |
| M14485 | BCI | BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5. |
| M14481 | 3α-Aminocholestane | 3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM. |
| M11444 | ABBV-CLS-484 | ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function. |
| M11433 | PTP1B-IN-1 | Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues. |
| M11432 | Razuprotafib | Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM). |
| M11340 | RMC-4630 | Rmc-4630 (SHP2-IN-7) is a SHP2 inhibitor. |
| M11097 | Uralenol | Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor. |
| M10739 | SPI-112 | SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor of SHP2, protein tyrosine phosphatase (PTP) and PTP1B IC50 1 μM, 18.3 μM, and 14.5 μM, respectively. |
| M10738 | IACS-13909 | IACS-13909 is a potent selective, orally active SHP2 allosteric inhibitor IC50 for 15.7 nM,Kd 32 nM. IACS-13909 is more selective for SHP2 than other phosphatase, including SHP1. IACS-13909 inhibits the signaling of the receptor tyrosine kinase (RTK)/MAPK pathway and has an anticancer effect. |
| M10582 | Rbin-1 | Rbin-1 (ribozinoindole-1) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 136 nM in wild-type cells). |
| M10478 | Voclosporin (ISATX247) | Voclosporin (VCS, ISATX247) is a novel calcineurin (PP2B) (CN) inhibitor. |
| M10278 | Raphin1 | Raphin1 is an orally bioavailable, selective R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1) inhibitor, strongly binding to the R15B-PP1c holophosphatase with Kd of 33 nM. |
| M10027 | C2 Ceramide | C2 Ceramide (N-Acetyl-D-sphingosine) is a cell-permeable and biologically active ceramide, it induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases. |
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