| Cat.No. | Name | Information |
|---|---|---|
| M2030 | Apremilast | Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM. |
| M6804 | IBMX | IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. |
| M5959 | Sildenafil | Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM. |
| M5939 | Rolipram | A selective inhibitor of PDE4, Rolipram, inhibits immunopurified PDE4B and PDE4D activity with IC50 of 130 nM and 240 nM, respectively. It has anti-inflammatory activity. Rolipram also increased cAMP levels and activated PKA, which in turn increased proteasome activity and inhibited tau aggregation. |
| M5833 | Olprinone | Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. |
| M5174 | Icariin | Icariin is a flavonol glycoside. Icariin inhibited PDE5 and PDE4 activity with IC50 of 432 nM and 73.50 μM, respectively. Icariin is also a PPARα activator. Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoiesis, immunity and bone metabolism. |
| M5060 | Propentofylline | Adamantane derivatives, processes for their preparation and pharmaceutical composition containing them. |
| M4964 | HA130 | HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. |
| M4851 | TAK-063 | TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM. |
| M4397 | Fraxin | Fraxin is a glucoside of fraxetin, an O-methylated coumarin. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme. Fraxin was administered orally to rats to investigate its metabolism. |
| M3700 | PF8380 | Pf-8380 is a potent autotaxin inhibitor with IC50 of 2.8 nM and 101 nM in in vitro enzyme assay and human whole blood cell assay, respectively. |
| M3587 | Dyphylline | Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. |
| M3566 | Vardenafil hydrochloride Trihydrate | Vardenafil hydrochloride Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
| M3557 | Dipyridamole | Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. |
| M3473 | Tadalafil | Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM. |
| M3447 | PF-2545920 | PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. |
| M3437 | Cilomilast | Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
| M3434 | Pimobendan | Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
| M3394 | Deltarasin | Deltarasin is a novel small molecule which inhibits the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling. |
| M3375 | S-(+)-Rolipram | S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
| M3337 | Milrinone | Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE. |
| M3259 | Irsogladine | Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. |
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