Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M10081 | Omaveloxolone | Omaveloxolone (RTA 408) is a first-in-class antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO). Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway. |
| M8710 | Brusatol | Brusatol (NSC 172924) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2. |
| M8692 | ML385 | ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1. |
| M3988 | Sulforaphane | Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. |
| M58515 | CDDO-TFEA | CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models. |
| M54409 | TAT-14 | TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. |
| M39208 | Artemisitene | Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability. |
| M28606 | CPUY192018 | CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM. |
| M21431 | Ezetimibe ketone | Ezetimibe ketone (EZM-K) is a phase I metabolite of Ezetimibe. Ezetimibe is an NPC1L1 inhibitor, and Ezetimibe inhibits intestinal cholesterol absorption by preventing the absorption of cholesterol by the NPC1L1 protein. It is a potent Nrf2 activator. |
| M20956 | Diroximel Fumarete | Diroximel Fumarete, also known as ALKS-8700, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. Diroximel fumarate is a Nrf2 activator. |
| M19174 | Halleridone | Halleridone is a natural product isolated from Halleria lucida (Scrophulariaceae), Teucrium decipiens, Phyla nodiflora and the stems of the plant Cornus walteri. Halleridone activated Nrf2-mediated HO-1 expression and inhibited Aβ1-42-overexpressed microglial BV-2 cell activation. |
| M18767 | L-Sulforaphane | L-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. |
| M18229 | Eriodictyol 7-O-glucoside | Eriodictyol 7-O-glucoside |
| M17266 | Gingerenone A | Gingerenone A is a Nrf2-Gpx4 activator. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. |
| M14596 | Nrf2-IN-1 | Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). |
| M14595 | NK-252 | NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential. |
| M14594 | KI696 | KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction. |
| M14593 | Keap1-Nrf2-IN-1 | Keap1-Nrf2-IN-1 is a Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. |
| M14592 | CDDO-EA | CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator. |
| M14591 | (+)-DHMEQ | (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ. |
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