| Cat.No. | Name | Information |
|---|---|---|
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M9082 | ISO-1 | ISO-1, also known as MIF Antagonist, is a MIF inhibitor with an IC50 of 7 uM. ISO-1 exerts anti-cancer effects on PANC-1 cell proliferation, migration and invasion in vitro, and inhibited PANC-1 cell-induced tumour growth in xenograft mice in vivo. |
| M30795 | INF4E | INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction. |
| M21531 | GDC-2394 | GDC-2394 is an oral inhibitor of NLRP3 inflammasome. The NLRP3 inflamome, the best studied and most characterized, also inhibits IL-1β with IC50 of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). |
| M17597 | Britanin | Britanin is an NLRP3 inhibitor with an IC50 of 3.630 μM. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. |
| M17240 | Methyl gallate | Methyl gallate is a polyphenol commonly found in the plant kingdom and is also an inhibitor of NLRP3, inhibiting the activation of NLRP3 inflammatory vesicles. In vitro, Methyl gallate is also a potent, highly specific inhibitor of herpes simplex virus (HSV) and has the ability to inhibit Treg cell migration. |
| M10839 | JC-171 | JC-171 is a selective inhibitor of NLRP3 inflammasomes that inhibits the release of IL-1β by macrophages induced by LPS/ATP IC50 The value is 8.45 μM. |
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