| Cat.No. | Name | Information |
|---|---|---|
| M4005 | PDTC | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective and blood-brain barrier (BBB) permeable nuclear factor-κB (NF-κB) inhibitor. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M9331 | Royal Jelly acid | Royal Jelly acid (10-hydroxy-2-decenoic acid) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
| M3161 | Betulinic acid | Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome. |
| M4516 | Sinomenine-Hydrochloride | Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid derived from Sinomenium Acutum, is a blocker of NF-κB activation. Sinomenine is also a μ-opioid receptor activator. |
| M4506 | Morusin | Morusin is a prenylated flavonoid isolated from Morus alba Linn., which could inhibit NF-κB and STAT3 activity. Morusin has various biological activities, such as antitumor, antioxidant, and anti-bacteria property. |
| M4504 | Sanggenone-C | Sanggenon C is a flavanone diels-Alder adduct compound isolated from the root bark of the genus Morus Cathayana. |
| M4481 | Mangiferin | Mangiferin is an Nrf2 activator. Mangiferin inhibits nuclear translocation of NF-κB subunit P65 and P50. Mangiferin has antioxidant, anti-diabetic, anti-hyperuricemia, antiviral, anticancer and anti-inflammatory activities. |
| M4455 | 5-O-Methylvisammioside | 5-O-methylvisammioside isa natural compound isolated from parsnip. |
| M4412 | Picroside-II | Picroside II lutein II is a iridoid compound extracted from Lutein, which has anti-inflammatory and anti-apoptotic effects. |
| M4407 | Demethyleneberberine | Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates colitis and inhibits inflammation in mice by inhibiting the NF-κB pathway and regulating Th cell balance. Demethyleneberberine can be used as an AMPK activator in the study of non-alcoholic fatty liver disease (NAFLD). |
| M4353 | Myrislignan | Myrislignan is a lignan isolated from Myristica Fragrans Houtt with anti-inflammatory activity. Myrislignan mitigated LPS-induced inflammation in mouse macrophages by inhibiting the activation of the NF-KB signaling pathway. |
| M4351 | Dehydrodiisoeugenol | Dehydrodiisoeugenol was isolated from Myristica Fragrans Houtt with anti-inflammatory and antibacterial effects. Dehydrodiisoeugenol inhibited NF-κB activation and cycde-2 gene expression in LPS-stimulated mouse macrophages. |
| M4345 | Barlerin | Barlerin (8-O-acetyl Shanzhiside methyl ester) is a cyclosporin glucoside isolated from folk medicinal plants in Xizang, China. Barlerin (8-O-acetyl Shanzhiside methyl ester) inhibited NF-κB activity. |
| M4278 | Rhynchophylline | Rhyncholphylline is a kind of alkaloid compound isolated from Uncaria. It has high biological activity and has been widely used in anti-inflammatory and neuroprotective studies. |
| M4276 | Tyrosol | Tyrosol is a derivative of phenyl ethanol. Tyrosol attenuates pro-inflammatory cytokines from astrocytes and decreases NF-κB activation. It has antioxidant and anti-inflammatory effects. |
| M4249 | Schisandrol B | Schisandrol B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities. |
| M4230 | Armepavine | Armepavine is an active compound from Nelumbo Nucifera, which not only has anti-inflammatory effect on human peripheral blood monocytes, but also has immunosuppressive effect on T lymphocytes and lupus nephritis mice. Armepavine inhibits TNF-α - induced MAPK and NF-κB signaling cascade. |
| M4228 | Neferine | Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| M4187 | Senegenin | Tenuigenin is the main active ingredient isolated from the roots of Polygala tenuifolia. Tenuigenin prevents staphylococcus aureus-induced pneumonia by inhibiting NF-κB activation. |
| M4179 | Neochlorogenic-acid | Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid can inhibit the production of TNF-α and IL-1β. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibited the activation of phosphorylated NF-κB P65 and P38 MAPK. |
| M4126 | Zingerone | Zingerone (Vanillylacetone) is a non-toxic methoxyphenol obtained from ginger. It has anti-inflammatory, anti-diabetes, anti-lipid allergy, anti-diarrhea, anti-spasticity and anti-tumor activities. Zingerone reduces oxidative stress and inflammation and down-regulates NF-κB signaling. Zingerone acts as an anti-mitotic agent and inhibits the growth of neuroblastoma. |
| M4092 | Ginsenoside-Rk1 | Ginsenoside Rk1 is a high-temperature processed extract of ginseng. Ginsenoside Rk1 has anti-inflammatory effects and inhibits Jak2/Stat3 signaling pathway and NF-κB activation. |
| M4091 | Ginsenoside-Rg6 | Ginsenoside Rg6 inhibited NF-κB transcriptional activity induced by TNF-α in HepG2 cells with IC50 of 29.34 μM. Ginsenoside Rg6 also induced apoptosis. |
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