| Cat.No. | Name | Information |
|---|---|---|
| M4005 | PDTC | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective and blood-brain barrier (BBB) permeable nuclear factor-κB (NF-κB) inhibitor. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M9331 | Royal Jelly acid | Royal Jelly acid (10-hydroxy-2-decenoic acid) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
| M3161 | Betulinic acid | Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome. |
| M9825 | Helenalin | Helenalin is an anti-inflammatory sesquiterpene lactone, it selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin effectively inhibits C/EBPβ at least 10 times higher than that for NF-κB (EC50 values were determined between 0.1 and 0.4 μM for C/EBPβ). |
| M9645 | Licochalcone D | Licochalcone D is a potent inhibitor of NF-kappaB (NF-κB) p65 with antioxidant, anti-inflammatory, anti-cancer properties. |
| M9456 | Berbamine dihydrochloride | Berbamine dihydrochloride is a novel inhibitor of NF-κB, inhibits growth and induces apoptosis in human myeloma cells. |
| M8984 | Denosumab | Denosumab is designed to target RANKL (RANK ligand), a protein that acts as the primary signal to promote bone removal/resorption. |
| M8600 | Urolithin B | Urolithin B is a natural product with antiproliferative and antioxidant activity. |
| M8436 | Ethacrynic acid | Ethacrynic acid is a non-sulfa ring diuretic used to study hypertension and swelling caused by congestive heart failure, among other conditions. |
| M7752 | Sodium diethyldithiocarbamate trihydrate | Sodium diethyldithiocarbamate trihydrate is a chelating agent, generally used in mobilizing toxic metals from the human tissues and experimental animals. Sodium diethyldithiocarbamate trihydrate inhibits induction of macrophage nitric oxide synthase. |
| M7633 | Bicyclol | Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Dicyclol is an anti-hepatitis compound used in studies of chronic hepatitis B and C in China. |
| M6444 | Andrographolide | Andrographolide is a NF-κB inhibitor that inhibits NF-κB activation by covalently modifying the cysteine residue of P50 in endothelial cells without affecting IκBα degradation or p50/ P65 nuclear translocation. Andrographolide has antiviral effects. |
| M4786 | Aristolochic acid A | Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells. |
| M4756 | Berbamine | Berbamine is a natural compound extracted from the traditional Chinese medicine Phellodendron amurense, which has anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker. |
| M4721 | Engeletin | Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb., it inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects. |
| M4716 | Sauchinone | Sauchinone is a diastereoisomer lignan obtained from Saururus chinensis. Sauchinone inhibited LPS induced expression of iNOS, TNF-α and COX-2 by inhibiting phosphorylation of I-κBα and nuclear translocation of P65. Sauchinone has anti-inflammatory and antioxidant activities. |
| M4685 | Obtusifolin | Obtusifolin, a new coumarin from roots of Haplophyllum obtusifolium, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. |
| M4680 | Mollugin | Mollugin is Rubia Cordifolia L. Is a major bioactive ingredient in the. Mollugin has anticancer effects by inhibiting NF-κB activation induced by TNF-α. Mollugin can enhance the osteogenic effect of BMP-2 through the P38-Smad signaling pathway. |
| M4608 | Swertiamarin | Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. |
| M4591 | Sodium-Aescinate | Sodium Aescinate is a triterpenoid saponin from Aesculus hippocastanum seeds with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits liver cancer growth by targeting the CARMA3/NF-κB pathway. |
| M4550 | Maslinic-acid | Maslinic-acid (MA) is a natural triterpenoid with a wide range of biological activities, such as anti-tumor, anti-diabetes, antioxidant, heart-protective, neuroprotective, anti-parasitic and growth stimulating, Maslinic acid inhibited THE DNA binding activity of NF-κB P65 and eliminated the PHOSPHORylation of IκB-α. |
| M4533 | Dauricine | Dauricine is a diphenylisoquinoline alkaloid isolated from Asiatic Moonseed Rhizome and has anti-inflammatory activity. Dauricine inhibited proliferation, invasion and apoptosis of colon cancer cells in a dose-dependent manner by inhibiting NF-κB activation. |
| M4523 | Specnuezhenide | Specnuezhenide ((8E)-Nuezhenide) was separated from the fruit of the ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) inhibited IL-1β -induced chondrocyte inflammation by inhibiting NF-κB and WNT /β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) showed anti-inflammatory effects in rat models of osteoarthritis (OA). |
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