| Cat.No. | Name | Information |
|---|---|---|
| M4005 | PDTC | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective and blood-brain barrier (BBB) permeable nuclear factor-κB (NF-κB) inhibitor. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M9331 | Royal Jelly acid | Royal Jelly acid (10-hydroxy-2-decenoic acid) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
| M3161 | Betulinic acid | Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome. |
| M39218 | Kamebakaurin | Kamebakaurin is a natural compound isolated from Rabdosia excisa. Kamebakaurin is a potent inhibitor of NF-κB activation by directly targeting DNA-binding activity of p50. |
| M39215 | Eurycomalactone | Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. |
| M39213 | Dehydromiltirone | Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. |
| M31397 | Myrcene | Myrcene is a monoterpene compound found in many plants that inhibits both MAP kinase and NF-κB pathways, thereby suppressing colonic inflammation. |
| M30703 | 12-Oxo phytodienoic acid | 12-Oxo phytodienoic acid (12-OPDA, 12-oxo phytodienoic acid) is a plant lipid-derived compound with anti-inflammatory activity that inhibits neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in cells activated by lipopolysaccharide (LPS).12-Oxo phytodienoic acid can be used in the study of neurodegenerative diseases. |
| M29555 | NF-κΒ activator 2 | NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS). |
| M28589 | SP-100030 | SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA). |
| M25465 | B022 | B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 4.2 nM and IC50 of 15.1 nM. B022 protects liver from toxin-induced inflammation, oxidative stress and injury. |
| M25407 | SN52 | SN52 is a novel potent, competitive, and cell-permeable inhibitor of nuclear factor-kappaB (NF-κB). SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. |
| M21470 | CDDO-dhTFEA | CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound that effectively activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. |
| M21403 | CORM-3 | CORM-3 is a carbon monoxide-releasing molecule that attenuates nuclear ectopic NF-κB p65, reduces ROS production, and increases intracellular glutathione and superoxide dismutase levels.CORM-3 reduces the activation of NLRP3 inflammatory vesicles. |
| M20672 | INH14 | INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively. |
| M19371 | Handelin | Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production. |
| M19347 | Nimbolide | Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways. |
| M19176 | Sappanone A | Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. |
| M18964 | Nervonic Acid | Nervonic Acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. |
| M18884 | Sciadopitysin | Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1. |
| M18713 | Chelidonic acid | Chelidonic acid is an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. |
| M18529 | Deoxyelephantopin | Deoxyelephantopin is a natural bioactive sesquiterpene lactone which has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling. |
| M18255 | Hesperidin methylchalcone | Hesperidin methylchalcone is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. |
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