Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M9051 | FCCP | FCCP is a mitochondrial uncoupling agent and an oxidative phosphorylation (OXPHOS) inhibitor. FCCP is often used as an apoptosis inducer. |
| M10919 | Mito-TEMPO | Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting the formation of peroxynitrite. Mito-TEMPO treatment inhibits APAP-induced EXPRESSION OF RIP3 kinase. |
| M20774 | CTPI-2 | CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). |
| M14653 | AP39 | AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. |
| M14463 | Afzelin | Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. |
| M11519 | IMT1 | IMT1 is the first, specific and non-competitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 induces conformational changes in POLRMT that block substrate binding and transcription in a dose-dependent manner in vitro. IMT1 reduced deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in significant depletion of cellular amino acid levels. |
| M11226 | VLX600 | VLX600 is a novel inhibitor of iron-chelated oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and can show enhanced cytotoxicity in nutrient deficiency conditions. VLX600 showed selective cytotoxic activity against malignant cells and induced autophagy and had anticancer activity.*The compound is unstable in solutions, freshly prepared is recommended |
| M10336 | KL1333 | KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. |
| M9911 | Lixumistat | Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat (IM156) is a metformin derivative, which increases AMPK phosphorylation. |
| M3315 | Thiabendazole | Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. |
| M59406 | T-271 | T-271 is a selective inducer of mitochondrial autophagy. |
| M59175 | FC9402 | FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation. |
| M58607 | OPC-163493 | OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. |
| M56714 | Antimalarial agent 14 | Antimalarial agent 14 is a potent inhibitor of mitochondrial electron transport. |
| M55651 | IM176OUT05 | IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM. IM176OUT05 is a high solubility biguanide. |
| M52573 | Speract | Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism. |
| M42508 | BTM-3566 | BTM-3566 is an OMA1 activator. |
| M42506 | SCAL-266 | SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. |
| M42505 | SCAL-255 | SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 1.14 μM. |
| M42504 | ND-011992 | ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. |
| M42503 | GNX-865 | GNX-865 is a mitochondrial permeability transition pore (mPTP) inhibitor that protects against ischemia-reperfusion injury in vivo. |
| M42502 | HP661 | HP661 is an orally available oxidative phosphorylation (OXPHOS) inhibitor that effectively blocks the activity of mitochondrial complex I and reduces the production of the reactive oxygen species. |
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