Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M10919 | Mito-TEMPO | Mito-TEMPO (MT) is a mitochondrial-targeted superoxide dismutase mimetic that protects the early stages of acetaminophen (APAP) hepatotoxicity by inhibiting the formation of peroxynitrite. Mito-TEMPO treatment inhibits APAP-induced EXPRESSION OF RIP3 kinase. |
| M9051 | FCCP | FCCP is a mitochondrial uncoupling agent and an oxidative phosphorylation (OXPHOS) inhibitor. FCCP is often used as an apoptosis inducer. |
| M66211 | Ru265 | Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor. |
| M58968 | Mito-Lonidamine | Mito-Lonidamine (Mito-LND) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-Lonidamine inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells. |
| M58540 | Mitochondrial fusion promoter M1 | Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 (2 mg/kg; iv) alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury. |
| M58487 | NL-1 | NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50 values of 47.35 μM and 56.26 μM, respectively. |
| M58261 | Malonyl CoA lithium | Malonyl CoA lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). Malonyl Coenzyme A lithium (Malonyl CoA lithium) is an important precursor for the production of a variety of chemicals that modulate insulin-stimulated glucose transport in myotubes. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. |
| M56716 | MFI8 | MFI8 is a small molecule inhibitor of mitochondrial. |
| M56715 | GW604714X | GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. |
| M55258 | THP104c | THP104c is a mitochondrial fission inhibitor. |
| M54715 | ZK53 | ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. |
| M42507 | HPPE | HPPE (Bach1-IN-1) is an orally active, potent Bach1 inhibitor. |
| M40615 | Ferulenol | Ferulenol is a sesquiterpene-based coumarin derivative isolated and purified from Ferula vesceritensis that causes inhibition of oxidative phosphorylation. At low concentrations, it can inhibit ATP synthesis by inhibiting adenine nucleotide translocase, and has pro-oxidant and anti-cancer activities. In addition, Ferulenol also induces specific inhibition of succinate ubiquinone reductase without altering the succinate dehydrogenase activity of complex II. Ferulenol can be used to study the physiological role of mitochondrial complex II and electron transport mechanisms. |
| M31395 | 1-Hexanol | 1-Hexanol is a tertiary alcohol that also acts as a surfactant and uncouples mitochondrial respiration by a nonprotonic mechanism. |
| M30822 | S3QEL-2 | S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation. |
| M30598 | Imeglimin | Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function. |
| M30006 | MCU-i4 | MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target. |
| M22353 | Fumarate hydratase-IN-1 | Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. |
| M21615 | MitoTEMPOL | MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. |
| M21139 | Ninerafaxstat trihydrochloride | Ninerafaxstat trihydrochloride shifts cellular metabolism to glucose oxidation from fatty acid oxidation. Ninerafaxstat trihydrochloride improves overall mitochondrial respiration and reduces fatty acid oxidation, thereby inhibiting the proliferation and growth of cancer cells. |
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