| Cat.No. | Name | Information |
|---|---|---|
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M3912 | Vinblastine sulfate | Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase. |
| M1940 | Docetaxel | Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
| M2888 | Noscapine hydrochloride | Noscapine, a phthalideisoquinoline alkaloid constituting 1–10% of the alkaloid content of opium, has been used as a cough suppressant. |
| M2274 | Fosbretabulin disodium | Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. |
| M1911 | NPI-2358 | NPI-2358 is a novel vascular disrupting agent (VDA) with an IC50 of 15 nM. |
| M1892 | Vincristine sulfate | Vincristine, formally known as leurocristine, is a mitotic inhibitor used in cancer chemotherapy. |
| M1642 | ABT-751 | ABT-751 is an orally bioavailable tubulin inhibitor with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively. |
| M59319 | Combretastatin A-1 | Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. |
| M58957 | Nab-Paclitaxel | Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel. Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. |
| M58416 | CCB02 | CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. |
| M56000 | Lisavanbulin | Lisavanbulin (BAL-101553) is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862). |
| M55999 | 20-O-Demethyl-AP3 | 20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. |
| M55998 | Lisavanbulin dihydrochloride | Lisavanbulin (BAL-101553) dihydrochloride is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862). |
| M53349 | P34cdc2 Kinase Fragment | P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. |
| M53348 | Cemadotin | Cemadotin (LU103793) is an analogue of Dolastatin 15 which is naturally occurring cytotoxic peptides. |
| M49546 | ENMD-1198 | ENMD-1198 (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. |
| M49523 | Tubulin/JAK2-IN-1 | Tubulin/JAK2-IN-1 is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. |
| M49522 | S-72 | S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling. |
| M44985 | Podophyllotoxinone | Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization. |
| M41544 | ER degrader 7 | ER degrader 7 is an ERα and ERβ degrader. |
| M41543 | Tubulin inhibitor 34 | Tubulin inhibitor 34 is a potent anticancer agent. |
| M41542 | EAPB 02303 | EAPB 02303 is a microtubule-disrupting agent and inhibitor. |
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