| Cat.No. | Name | Information |
|---|---|---|
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M3912 | Vinblastine sulfate | Vinblastine sulfate is an anti-mitotic agent which arrests the cell cycle in the G2/M-phase. |
| M1940 | Docetaxel | Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. |
| M5068 | ELR510444 | ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein compound transporter and retains activity in βIII-tubulin-overexpressing cell lines. |
| M5042 | MMAD | Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody compound conjugate. |
| M5041 | MMAF | Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody compound cytotoxin.*The compound is unstable in solutions, freshly prepared is recommended |
| M5039 | 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility. |
| M4975 | Cevipabulin | Cevipabulin (TTI-237) is a novel, potent, oral, microtubule-active antitumor small molecule, inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line. |
| M4857 | Epothilone B | Epothilone B (EPO906, Patupilone) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
| M4780 | 4-Demethylepipodophyllotoxin | 4 '- Demethylepipodophyllotoxin (4' - DMEP) is an intermediate compounds, can inhibit microtubule assembly. |
| M4417 | 7-Epitaxol | 7-Epi-Taxol is the active metabolite of Taxol, which has similar effects to Taxol in inhibiting cell proliferation, microtubule dissociation and inducing microtubule polymerization. |
| M4416 | Cephalomannine | Cephalomannine is a taxol alkaloid analogue that can be isolated from most tricuspid taxus species. Cephalomannine is an orally active anti-tumor agent that can be used as a chemotherapy agent for cancer research. |
| M4347 | Vinblastine | Vinblastine |
| M4346 | Vindoline | Vindoline is a Catharanthus roseus alkaloid that has a weak inhibitory effect on the self-assembly of tubulin. |
| M3901 | Combretastatin A4 | Combretastatin A4 (CA-4), which is a natural stilbene isolated from Combretum caffrum, is a microtubule-destabilizing agent that binds to the colchicine domain on β-tubulin and exhibits a lower toxicity profile than paclitaxel or the Vinca alkaloids. |
| M3768 | Ixabepilone | Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. |
| M3755 | D-64131 | D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). |
| M3741 | Monomethyl auristatin E | Monomethyl auristatin E (MMAE; Vedotin) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.*The compound is unstable in solutions, freshly prepared is recommended |
| M3723 | Vinflunine | Vinflunine (VFL) is a bifluorinated tubulin-targeted agent of the vinca alkaloids class active in advanced stage breast cancer. |
| M3492 | CYT997 | CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. |
| M3460 | Colchicine | Colchicine is a natural product extracted from Colchicum spp. It is also a tubulin inhibitor and microtubule disruptor with an IC50 of 3 nM for inhibition of microtubule polymerization, and a competitive antagonist of α3 glycine receptors (GlyRs). Colchicine is also a competitive antagonist of α3 Glycine receptors (GlyRs) and has been used in gout research. |
| M3120 | Vinorelbine Tartrate | Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. |
| M3086 | Triclabendazole | Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. Triclabendazole induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. |
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