| Cat.No. | Name | Information |
|---|---|---|
| M2225 | Thalidomide | Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM. |
| M9033 | VH-298 | VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, with a Kd value of 80 to 90 nM. |
| M1976 | Pomalidomide | Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM. |
| M58123 | OICR-8268 | OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can be used in the development of DCAF1-based PROTACs. |
| M57120 | VH 101, acid | VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. |
| M57119 | (S,R,S)-AHPC-Boc | (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
| M57118 | Lenalidomide-Br | Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. |
| M57117 | CRBN modulator-1 | CRBN modulator-1, a Thalidomide analog and a CRBN modulator, has an IC50 of 3.5 μM and a Ki of 0.98 μM. |
| M57116 | Lenalidomide-4-OH | Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. |
| M57115 | (S,R,S)-AHPC TFA | (S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
| M57114 | Nutlin carboxylic acid | Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. |
| M57113 | cIAP1 ligand 1 | cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. |
| M57112 | Pomalidomide-piperazine | Pomalidomide-piperazine is an active compound that can be used to synthesis the E3 ligand for PROTAC. |
| M57111 | (S,R,S)-AHPC dihydrochloride | (S,R,S)-AHPC (VH032-NH2) dihydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
| M43915 | 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
| M43914 | 2,6-Bis(benzyloxy)pyridine-3-boronic acid | 2,6-Bis(benzyloxy)pyridine-3-boronic acid |
| M43912 | 2,6-bis(benzyloxy)pyridin-3-amine | 2,6-bis(benzyloxy)pyridin-3-amine |
| M43910 | 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione | 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione |
| M43905 | 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]- | 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]- |
| M43904 | 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)- | 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)- |
| M43903 | 2,6-Piperidinedione, 3-[[6-(1-piperazinyl)-3-pyridinyl]amino]- | 2,6-Piperidinedione, 3-[[6-(1-piperazinyl)-3-pyridinyl]amino]- |
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