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Histone Methyltransferase Histone methyltransferase

Cat.No.  Name Information
M2358 3-Deazaneplanocin A 3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
M9151 MI-503 MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM.
M5412 Amodiaquin dihydrochloride dihydrate Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent.
M56065 MS8511  MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM (G9a) and 140 nM (GLP), and Kd values of 44 nM (G9a) and 46 nM (GLP).
M56064 TM2-115  TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.
M56063 (R)-HH2853  (R)-HH2853 is a mutant EZH2 inhibitor with an IC50 of <100 nM for EZH2-Y641F.
M56062 G9a-IN-1  G9a-IN-1 is a G9a protein inhibitor.
M56061 OTS193320  OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor.
M56060 PRMT5-IN-9  PRMT5-IN-9 is a novel PRMT5 inhibitor for researching cancer, with an IC50 of 0.01 μM.
M56059 UNC8153 TFA  UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM.
M56058 EED ligand 1  EED ligand 1 is a diverse, potent, and efficacious inhibitor that target the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase.
M56057 CM-579 trihydrochloride  CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively.
M56056 EPZ011989 hydrochloride  EPZ011989 hydrochloride is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor, with a Ki value of <3 nM.
M53317 SAH-EZH2 SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor.
M53316 UNC4976 UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.
M53315 C21 C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM.
M41699 EZH2-IN-15 EZH2-IN-15 (SHR2554) is a EZH2 inhibitor.
M41698 NSD-IN-2 NSD-IN-2 is a potent and irreversible NSD1 inhibitor.
M41697 MS9715 MS9715 is a potent and seletive NSD3-targeting PROTAC.
M41696 NSD2-IN-4 NSD2-IN-4 is a potent and selective NSD2-SET inhibitor.
M41695 PRMT4-IN-1 PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM).
M41694 WM-662 WM-662 is a WDR5-MYC interaction inhibitor, with an IC50 of 18 μM.
M41693 PRMT5-IN-25 PRMT5-IN-25 is a potent PRMT5 inhibitor with an Ki value of 0.06 nM.




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