| Cat.No. | Name | Information |
|---|---|---|
| M2358 | 3-Deazaneplanocin A | 3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM. |
| M9151 | MI-503 | MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. |
| M5412 | Amodiaquin dihydrochloride dihydrate | Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent. |
| M7458 | UNC3866 | UNC3866 is a high affinity CBX4 and CBX7 inhibitor. UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel. |
| M6592 | Chaetocin | Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM. |
| M6362 | A 196 | A-196 is a potent selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively, and biochemically inhibits SUV4-20 in a substrate-competitive manner. In addition, A-196 is a first-in-class chemical probe for SUV4-20, which can be used to study the role of histone methyltransferases in genome integrity. |
| M6336 | 3-Deazaneplanocin A hydrochloride | 3-Deazaneplanocin A hydrochloride（DZNep HCl） is a eZH2 histone methyltransferase inhibitor. |
| M6288 | LLY-507 | LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2. LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50 <15 nM. |
| M5186 | CPI-360 | Cpi-360 is an effective selective EZH2 inhibitor with IC50 of 0.5 nM and 2.5 nM for WT EZH2 and Y641N EZH2, respectively. |
| M5128 | PFI-2 | PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. |
| M4813 | UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM. |
| M4804 | GSK-503 | GSK-503 is a potent EZH2 inhibitor with potential anticancer activity. |
| M3631 | AZ505 ditrifluoroacetate | AZ505 ditrifluoroacetate is a potent and highly selective inhibitor of the oncogenic protein SMYD2 (IC50=0.12 uM) with potential anticancer activity. |
| M3105 | UNC0646 | UNC0646 is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP with IC50 of 6 nM and 15 nM , respectively, with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. |
| M3103 | UNC0631 | UNC0631 is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP with IC50 of 6 nM and 15 nM, respectively, with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. |
| M3101 | UNC0224 | UNC0224 is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP with IC50 of 15 nM and 20 nM, respectively. |
| M2861 | MM-102 | MM-102 is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM. |
| M2675 | EPZ004777 hydrochloride | EPZ004777 hydrochloride is the hydrochloride salt of EPZ004777, which is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM. |
| M2334 | EPZ004777 | EPZ004777 is a potent, selective, small-molecule inhibitor of DOT1L with IC50 of 0.4 nM. |
| M2179 | EPZ-5676 | EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase. |
| M2024 | BIX 01294 Trihydrochloride | BIX 01294 Trihydrochloride is a potent inhitor of G9a histone methyltransferase with IC50 of 2.7 μM. |
| M58463 | WDR5-IN-4 | WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity. |
| M56066 | MS67 | MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. |
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