GPCR19/TGR5 GPCR19/TGR5

Cat.No.	Name	Information
M13985	Ursodeoxycholic acid sodium	Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism.
M13984	SB756050	SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.
M11152	Deoxycholic acid sodium salt	Deoxycholic acid sodium salt is a bile acid and a by-product of intestinal metabolism, Deoxycholic acid sodium salt can activate the G protein-coupled bile acid receptor TGR5.
M9727	SBI-115	SBI-115 is a TGR5 (GPCR19) antagonist, it decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
M9055	INT-777	INT-777 is a potent TGR5 agonist with EC50 of 0.82 μM. In animal models, INT-777 alleviates liver injury by activating TGR5, thereby increasing bile flow and reducing bile acid synthesis. TGR5 signalling mediated by INT-777 induces the release of GLP-1 (glucagon-like peptide-1), improving liver and pancreatic function in obese mice.
M5256	BAR 502	BAR502 is a dual agonist of FXR and GPBAR1 with IC50 values of 2 μM and 0.4 μM, respectively.
M2588	TGR5 Receptor Agonist	TGR5 Receptor Agonist is a potent TGR5(GPCR19) agonist which showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).