| Cat.No. | Name | Information |
|---|---|---|
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M5442 | Baclofen | Baclofen is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research. |
| M5653 | Flumazenil | Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
| M9114 | LAU159 | LAU159 is a potent, functionally selective α6β3γ2 GABAA receptor modulator. |
| M8879 | Aminooxy-acetic acid (AOA) hemihydrochloride | Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. |
| M8216 | Securinine | Securinine is an alkaloid widely in traditional folk medicine, it is a GABAA receptor antagonist. |
| M8151 | SR-95531 | SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities. |
| M8027 | Brexanolone | Brexanolone (Allopregnanolone) is a positive allosteric modulator of GABAA chloride channel. |
| M7813 | Isoguvacine hydrochloride | Isoguvacine hydrochloride is a GABAA receptor agonist. |
| M7691 | Chlormethiazole hydrochloride | Chlormethiazole hydrochloride is a GABAA agonist; glycine receptor modulator. Clomethiazole hydrochloride is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,4-methylenedioxymethamphetamine (MDMA). |
| M7607 | 5α-Androst-16-en-3α-ol | 5alpha-androst-16-en-3alp |
| M7442 | U 93631 | U 93631 is a gABA A receptor antagonist. |
| M7410 | THIP hydrochloride | THIP hydrochloride (Gaboxadol hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). |
| M7252 | SB 205384 | SB 205384 is a gABA A receptor modulator; slows current decay. |
| M7242 | Saclofen | Saclofen is a selective GABA B antagonist. |
| M6995 | MRK 016 | MRK 016 is a gABAA receptor inverse agonist selective for the α5-subtype (EC50 = 3 nM). |
| M6744 | Ganaxolone | Ganaxolone (CCD 1042) is A neuroactive steroid allopregnenolone analogue synthesized orally and is A selective, high-affinity positive sex modulator of γ -aminobutyrate-A (GABAA) receptor with anticonvulsant properties. Gannadone works through different binding sites with benzodiazepine binding sites and can be used in epilepsy studies related to cyclin-dependent kinase-like 5 (CDKL5) deficiency (CDD). |
| M6641 | Cyclothiazide | Cyclothiazide is a AMPA selective desensitization inhibitor. Cyclothiazide is a positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. |
| M6585 | CGP52432 | CGP 52432 is a potent, selective GABAB antagonist. |
| M6319 | 17-PA | 17-PA is a antagonist of neurosteroid potentiation and direct gating of GABA A. |
| M6245 | Basmisanil | Basmisanil is a highly selective GABAAα5 negative allosteric modulator. |
| M6195 | Propofol | Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties. |
| M6010 | Tiagabine HCl | Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
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