DNA/RNA Synthesis DNA/RNA Synthesis

Cat.No.	Name	Information
M2129	Temozolomide	Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M2223	Cisplatin	Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells.
M2289	5-Fluorouracil	5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools.
M2288	Carboplatin	Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2292	Cytarabine	Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
M1716	Gemcitabine Hydrochloride	Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM.
M5680	Gemcitabine	Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
M5277	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
M7515	Brivudine	Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
M9650	Triazavirin	Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments.
M8765	Compound C108	Compound C108 is a small molecule that exhibits cancer-selective cytotoxicity (Viability = 100%/MCF-10A vs. 50%/BT-474, 67%/4T1, 70%/MDA-MB-231 & MDA-MB-453 post 48 h 1 μM C108 treatment) and synergizes with low dose paclitaxel in reducing ALDH-positive tumor-initiating cells (TIC poulation = 56.6%/control, 60.6%/0.1 μM paclitaxel alone, 47.4%/1 μM C108 alone, 7.3%/combined treatment for 24 h in BT474 breast cancer cultures) by targeting stress granule-associated protein G3BP2 (GAP SH3 domain-binding protein 2).
M8672	CeMMEC13	CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1 with an an IC₅₀ value of 2.
M8669	L67	L67 is a potent and specific inhibitor of DNA ligase IIIα (LigIIIα) that preferentially targets mitochondrial LigIIIα resulting in mitochondrial dysfunction.
M8555	Pyrazofurin	Pyrazofurin is an orotidine-5’-monophosphate decarboxylase (ODCase, OMP decarboxylase) inhibitor that exhibit potent antiviral, anti-malarial and anti-trypanosomes activities.
M8522	FDI-6	FDI-6 is a potent and specific inhibitor of FOXM1 that blocks DNA binding.
M8490	6-Thio-2′-Deoxyguanosine	6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres.
M8400	Fialuridine	Fluuridine is a nucleoside antiviral compound. The compound showed significant mitochondrial toxicity. Fialuridine is also a DNA-directed DNA polymerase inhibitor that may be used to treat HBV infection and has potent activity against hepatitis B virus in vivo and in vitro. FIAU blocks DNA synthesis of human cytomegalovirus, hepatitis B and herpes simplex viruses.
M7793	E3330	Erenapursta (E3330) is a specific, orally active and selective inhibitor of AP endonuclease 1 redox domain.
M7780	116-9e	116-9e (MAL2-11B) is a blocker of Hsp40-Hsp70 binding thereby inhibiting the chaperone activity of Hsp70-Hsp40. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis.
M7506	5-methoxyflavone	5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
M6528	BRACO-19 trihydrochloride	BRACO-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death.
M6449	Aphidicolin	Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus.
M6332	Triapine	Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and it is a potent radiosensitizer.
M6306	Madrasin	Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.
M6264	Favipiravir	Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. Its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP) inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
M6053	Vidarabine	Vidarabine is effective against herpes simplex virus and varicella-zoster virus.
M6046	Uridine	Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.
M5836	Orotic acid (6-Carboxyuracil)	Orotic acid(6-Carboxyuracil) is a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme.
M5771	Mercaptopurine	Mercaptopurine (6-MP) inhibits neopurine synthesis by incorporating methyltransferase metabolites of Mercaptopurine into DNA and RNA.
M5767	Menadione (Vitamin K3)	Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

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DNA/RNA Synthesis DNA/RNA Synthesis

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