| Cat.No. | Name | Information |
|---|---|---|
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M2289 | 5-Fluorouracil | 5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| M5680 | Gemcitabine | Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. |
| M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
| M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| M9650 | Triazavirin | Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. |
| M10693 | H3B-8800 | H3B-8800 is an orally available small molecule modulator of splicing factor 3B subunit 1 (SF3B1). H3B-8800 binds SF3B1 and exhibits significant antitumor activity by eliminating disruption of mRNA splicing. |
| M10612 | 4-Nitroquinoline N-oxide | 4-Nitroquinoline N-oxide (4-NQO) corrects DNA damage through nucleotide excision repair. 4NQO may induce DNA damage by generating reactive oxygen species thought to be produced by the enzymatic reduction of its nitro group. |
| M10561 | IMP-1088 | IMP-1088 is a novel potent and selective blocker of N-myristoylation in cells. IMP-1088 is also a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. |
| M10506 | RK-33 | RK-33 is a first-in-class, potent and selective DDX3 (RNA helicase) inhibitor, it binds to DDX3 and abrogates its activity. |
| M10362 | Beaucage reagent | Beaucage reagent is a potent DNA cleavage agent. Beaucage reagent can be used for preparing phosphorothioate oligomers. |
| M10128 | L189 | L189 is a novel human DNA ligase inhibitor with IC50s of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. |
| M10080 | Saccharin 1-methylimidazole | Saccharin 1-methylimidazole (also known as SMI) is an activator for DNA and RNA synthesis. |
| M10037 | Lurbinectedin | Lurbinectedin, also known as PM01183, is a covalent DNA minor groove binder with potential antineoplastic activity. |
| M9970 | N-Nitrosodiethylamine (NDEA) | N-Nitrosodiethylamine (NDEA) belongs to the nitrosamines category of nitrogenous disinfection byproduct. |
| M9924 | Risdiplam | Risdiplam (also known as RG7916 and RO7034067) is a gene splicing modulator (neuromuscular disease) that distributes into the central nervous system (CNS) and peripheral tissues. |
| M9860 | Bleomycin A5 Hydrochloride | Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. |
| M9270 | COH29 | COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. |
| M9262 | Plicamycin | Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin has antineoplastic activity. |
| M9214 | GC7 Sulfate | GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. |
| M9180 | Pyridostatin Trifluoroacetate Salt | Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer, with a Kd of 490 nM. |
| M9179 | Nolatrexed 2HCl | Nolatrexed 2HCl, also known as AG337, is a thymidylate synthase inhibitor. |
| M9118 | Chebulinic acid | Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. |
| M9020 | TAS-102 | TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. |
| M8960 | LY2334737 | LY2334737 is an orally available valproic acid ester of gemcitabine, a broad-spectrum antimetabolite with antineoplastic activity. |
| M8860 | X80 | X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair. |
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