| Cat.No. | Name | Information |
|---|---|---|
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M2289 | 5-Fluorouracil | 5-Fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| M5680 | Gemcitabine | Gemcitabine (LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. |
| M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
| M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| M9650 | Triazavirin | Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. |
| M13651 | O6-Benzylguanine | O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. |
| M13650 | ML-60218 | ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. |
| M13649 | Branaplam | Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. |
| M13648 | Halofuginone hydrobromide | Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. |
| M13647 | Halofuginone | Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. |
| M13646 | Guanine | Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. |
| M13644 | Cytidine-5'-triphosphate | Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. |
| M13643 | Cytarabine hydrochloride | Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV. |
| M13639 | Adenine hemisulfate | Adenine hemisulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. |
| M13638 | Acelarin | Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
| M13637 | 5-Methylcytosine | 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. |
| M13558 | Tipiracil | Tipiracil is a thymidine phosphorylase (TPase) inhibitor. |
| M13368 | IMT1B | IMT1B (LDC203974) is a highly specific human mitochondrial RNA polymerase (POLRMT) inhibitor that inhibits mitochondrial DNA (mtDNA) expression. IMT1B has antitumor effects. |
| M13367 | Metarrestin (ML246) | Metarrestin (ML246) is a first-in-class, oral active and specific perinucleolar compartment (PNC) inhibitor. It can destroy the nucleolus structure and inhibit the transcription of RNA polymerase (Pol) I. Metarrestin blocks the development of metastasis and prolongs survival in mouse cancer models. |
| M11539 | PCNA-I1 | Pcna-i1 is an effective PCNA (proliferating cell nuclear antigen) inhibitor. Pcna-i1 can selectively bind PCNA trimers, and its Kd value ranges from 0.2 μM to 0.4 μM. Pcna-i1 inhibited the growth of tumor cells with an IC50 value of ~0.2 μM. |
| M11537 | Nusinersen | Nusinersen is an antisense oligonucleotide compound that modifies pre-messenger RNA splicing of the SMN2 gene, thereby promoting full-length SMN protein production. |
| M11535 | RG7800 | RG7800 is a small molecule SMN2 splicing modifier. RG7800 has the potential to be used in spinal muscular atrophy. RG7800 corrects selective splicing of the human SMN2 gene in the brain of a transgenic SMA model mouse, leading to an increase in SMN protein in the brain. |
| M11527 | BCH001 | BCH001 is a quinoline derivative and a selective PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in pluripotent stem cells induced by congenital keratosis (DC). BCH001 did not inhibit poly (A) -specific ribonucase (PARN) or several other polynucleotide polymerases. PAPD5 is A nonnormalized Poly (A) polymerase with an unconventional RNA binding motif. |
| M11341 | Tempo | Tempo is a free radical capturing antioxidant and a selective scavenging agent of ROS that disambiguates superoxides in catalytic cycles. Tempo can induce DNA strand breaking and can be used as an organic catalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects. |
| M11056 | NSC 617145 | NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor,IC50 The value is 230 nM. NSC 617145 inhibit WRN ATPase and induce double-strand rupture (DSB) and chromosomal abnormalities. NSC 617145 is selective to WRN and superior to BLM, FANCJ, ChlR1, RecQ, and UvrD helicases. |
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