| Cat.No. | Name | Information |
|---|---|---|
| M1825 | PCI-32765 | PCI-32765 (Ibrutinib) is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.46 nM. |
| M7536 | BMS-935177 | BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective. |
| M6907 | (Z)-LFM-A13 | LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 2.5 μM. |
| M6636 | CTA 056 | CTA 056 is a iTK inhibitor. |
| M5333 | Tirabrutinib | Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM. |
| M5306 | Acalabrutinib | Acalabrutinib(ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.BMX, and TEC, respectively) and no activity against EGFR. |
| M5257 | ONO-4059 hydrochloride | ONO-4059 (GS-4059) hydrochloride is highly potent and selective BTK inhibitor with an IC50 of 2.2 nM. |
| M5162 | ONO-4059 analogue | ONO-4059 analogue is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with IC50 of 23.9 nM. |
| M3704 | RN486 | RN486 is a Bruton's tyrosine kinase (Btk) inhibitor with an IC50 Value of 4.0 nM. |
| M3620 | CGI1746 | CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM. |
| M2718 | GDC-0834 | GDC-0834 is a novel potent and selective BTK inhibitor with IC50 of 5.9 nM. |
| M2536 | CNX-774 | CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM. |
| M2113 | Spebrutinib (AVL-292) | Spebrutinib (AVL-292) is an oral, potent and selective small molecule covalent inhibitor of Btk (IC50 < 0.5 nM). |
| M57190 | UBX-382 | UBX-382 is an orally available proteolysis-targeting chimeras (PROTACs) that target BTK to inactivate B-cell receptor signaling. |
| M57189 | GDC-0834 | GDC-0834 is a potent and selective BTK inhibitor. |
| M57188 | DD-03-171 | DD-03-171 is a BTK, IKFZ1 and IKFZ3 degrader, the BTK IC50 a value of 5.1 nM. |
| M57187 | N-piperidine Ibrutinib hydrochloride | N-piperidine Ibrutinib hydrochloride is a reversible Ibrutinib derivative. |
| M54669 | TL-925 | TL-925 is a potentially first-in-class Bruton's tyrosine kinase (BTK) inhibitor that targets mast cell-mediated ocular inflammation and hypersensitivity and can be used in studies related to dry eye. |
| M49783 | JAK3/BTK-IN-6 | JAK3/BTK-IN-6 is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. |
| M43478 | DBt-10 | DBt-10 is a potent BTK degrader. |
| M43477 | BTK-IN-27 | BTK-IN-27 is a BTK inhibitor (IC50: 0.2 nM). |
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