| Cat.No. | Name | Information |
|---|---|---|
| M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
| M3380 | Pitavastatin Calcium | Pitavastatin Calcium is a new type of statin. |
| M3497 | Simvastatin (MK 733) | Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. |
| M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M9765 | Dimethyl itaconate | Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). |
| M9059 | TBHQ | TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator. |
| M2049 | Metformin hydrochloride | Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro. |
| M9069 | AS1842856 | AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 30 nM. |
| M5961 | Silibinin | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
| M13568 | Liensinine Diperchlorate | Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. |
| M13567 | Leonurine | Leonurine is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. |
| M13566 | Isorhapontigenin | Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation. |
| M13564 | FMK 9a | FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay. |
| M13563 | AC-73 | AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. |
| M13562 | 20-Deoxyingenol | 20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. |
| M11298 | Oleanolic Acid | Oleanolic Acid (Oleanic Acid) is a natural compound with anticancer activity, widely distributed in edible and medicinal plants. It is related to betulinic Acid and has relatively non-toxic, anti-tumor, hepatoprotective and antiviral properties. |
| M11124 | Corynoxine B | Corynoxine B is a natural compound of indole alkaloid, a beclin-1-dependent autophagy inducer. |
| M10988 | Bergenin | Bergenin is a cell protection and antioxidant polyphenol found in many medicinal plants. Bergenin has a wide range of hepatoprotective, anti-inflammatory, immunomodulatory, anti-tumor, antiviral, and antifungal effects. |
| M10731 | ICCB-19 hydrochloride | ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds to the N-terminal domain of TRADD (TRADD-N), breaking its binding to TRADD-C and TRAF2. ICCB-19 hydrochloride is an indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and degradation of long-lived proteins. |
| M10546 | Indophagolin | Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. |
| M10277 | EN6 | EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). |
| M10257 | Glycycoumarin | Glycycoumarin is a bioactive coumarin of licorice, it inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress-mediated JNK and GSK-3-mediated mitochondrial pathway. |
| M10087 | Ginkgolide K | Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. |
| M9851 | GW406108X | GW406108X is a potent autophagy inhibitor, with a pIC50 6.37 (427 nM) against ULK1. |
| M9698 | D-(+)-Trehalose dihydrate | D-(+)-Trehalose is a non-reducing sugar, used as a food ingredient and pharmaceutical excipient. |
| M9610 | LC3-mHTT-IN-AN1 | LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound, interacts with both mutant huntingtin protein (mHTT) and LC3B. |
| M9457 | Lanatoside C | Lanatoside C is a cardiac glycoside, with IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. |
| M9155 | Autophinib | Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin with IC50 values of 90 and 40 nM, targeting the lipid kinase VPS34 with IC50 value of 19 nM in vitro. |
| M8783 | Lys05 | Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15. |
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