| Cat.No. | Name | Information |
|---|---|---|
| M65743 | AqF026 | AqF026 is an agonist of the water channel aquaporin-1. AqF026 potentiated the channel activity of human AQP1 by >20% but had no effect on channel activity of AQP4. AqF026 enhanced the osmotic transport of water across the peritoneal membrane but did not affect the osmotic gradient, the transport of small solutes, or the localization and expression of AQP1 on the plasma membrane in a mouse model of peritoneal dialysis. |
| M30015 | TC AQP1 1 | TC AQP1 1 (m-Phenylenediacrylic acid) is a potent AQP1 inhibitor. TC AQP1 1 inhibits AQP1-mediated water flux in oocytes, with an IC50 of 8 μM. |
| M18770 | Aristolactam I | Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. |
| M13499 | Bacopaside II | Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis. |
| M7407 | TGN 020 | TGN 020 is a aquaporin 4 (AQP4) channel blocker. |
| M55037 | DFP00173 | DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. |
| M27618 | Z433927330 | Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively. |
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