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Apoptosis Apoptosis related

Cat.No.  Name Information
M2206 TH-302 (Evofosfamide) TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM.
M9075 Etomoxir sodium salt Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
M10320 Chondroitin sulfate Chondroitin sulfate is a class of sulfated glycosaminoglycans that are linear polysaccharides consisting of repeating disaccharide units composed of uronic acid and N-acetylhexosamine, which has been widely used in the treatment of osteoarthritis.
M10566 Valepotriate Valepotriate has anti-epileptic and anti-cancer activities, it isolated from Valeriana jatamansi Jones.
M7755 Dehydroleucodine Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser; mast cell stabilizers.
M38844 Glyphosate Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants.
M4375 Hypericin Hypericin is an extract of Hypericum perforatum, which has strong antiviral effect and anti-tumor effect.
M16194 Boldine Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research.
M13519 Rhapontin Rhapontin (Rhaponiticin), a component of rhubarb (Rheum officinale Baillon), induces apoptosis resulting in suppression of proliferation of human stomach cancer KATO III cells.
M58126 Deferoxamine Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells.
M4757 1,2,3,4,6-pentagalloylglucose 1,2,3,4,6-pentagalloylglucose (Pentagalloylglucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway.
M4743 Jolkinolide-B Jolkinolide B is a diterpenoid with biological activity isolated from euphorbia officinalis root. It is known that Jolkinolide B can induce apoptosis of cancer cells.
M4739 Notopterol Notopterol is coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, pain-relieving and anti-inflammatory effects. Notopterol has potential for use in acute myeloid leukemia (AML).
M4688 Momordin-Ic Momordin-Ic is a SENP1 Inhibitor. Momordin Ic induces apoptosis through oxidative stress-regulated mitochondrial dysfunction.
M4683 Sclareol Sclareol was isolated from Salvia sclarea and showed anticancer activity. Sclareol has strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB), and human white blood cells. Sclareol can induce apoptosis.
M4668 Astragalin Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds.
M4580 Cyclovirobuxine Cyclovirobuxine D (CVB-D) is the main active ingredient of Buxus microphylla. Cyclovirobuxine D induces autophagy and reduces Akt and mTOR phosphorylation. Cyclovirobuxine D inhibits the proliferation of cancer cells by inhibiting cell cycle progression and inducing mitochondria - mediated apoptosis. Cyclovirobuxine D has the potential to be used in the study of heart failure caused by myocardial infarction.
M4564 Lobetyolin Lobetyolin is a bioactive compound isolated from Codonopsis Pilosula. Lobetyolin has anti-inflammatory, antioxidant and xanthine oxidase inhibitory activities. Lobetyolin also induces apoptosis by inhibiting ASCT2-mediated glutamine metabolism.
M4559 Ziyuglycoside-II Ziyuglycoside II from Sanguisorba officinalis L. Triterpenoid saponins extracted from the. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. It has anti-inflammatory and anticancer effects.
M4557 Dictamine Dictamnine (Dictamine) is cytotoxic to human cervical and colon cancer cells, and also has antibacterial and antifungal activities.
M4526 Benzoylpaeoniflorin Benzoylpaeoniflorin, a natural compound extracted from paeonia lactiflora, has the potential to be used in the study of coronary heart disease by reducing apoptosis.
M4511 Tectorigenin Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM.
M4508 Madecassoside Madecassoside is an anti-inflammatory pentacyclic triterpenoid isolated from a large bowl. Antioxidant and anti-aging effects.
M4496 Linderalactone Linderalactone is an important sesquiterpene lactone isolated from Radix Linderae. Linderalactone inhibits cancer cell growth by regulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. Linderalactone also inhibited the proliferation of lung cancer A-549 cells with an IC50 value of 15 µM.
M4492 Curcurbitacin-Iib Cucurbitacin IIb is the active ingredient in chorioides, which induces apoptosis and has anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α.
M4490 Protosappanin-B Protosappanin B is a polyphenol substance extracted from Sappanwood, which has anti-tumor effect. In human bladder cancer cells, it can induce apoptosis by arresting G1 phase of cell cycle.
M4489 Brazilin Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities.
M4477 Costunlide Costunlide is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells.
M4471 Loganin Loganin, the main iridoid glycoside in cornus officinalis, has anti-inflammatory and anti-shock effects.
M4462 Oroxin-B Oroxin B (OB) is a flavonoid isolated from the traditional Chinese herb Oroxylum indicum (L.) Vent. Oroxin B (OB) can inhibit hepatoma cells by up-regulating PTEN, down-regulating COX-2, VEGF, PI3K and P-Akt, and induce early apoptosis. Oroxin B (OB) induces suppressive ER stress in malignant lymphoma cells.




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