| Cat.No. | Name | Information |
|---|---|---|
| M3132 | WZ4003 | WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases. |
| M2238 | Dorsomorphin dihydrochloride | Dorsomorphin (BML-275; Compound C) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. |
| M3946 | BML-275 | BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays. |
| M4897 | AICAR | AICAR is an adenosine analog and activator of AMPK that regulates glucose and lipid metabolism and inhibits the production of pro-inflammatory cytokines and iNOS. In addition, AICAR is an inhibitor of autophagy, YAP and mitophagy. |
| M8095 | PF-06409577 | Pf-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 subtype with an EC50 value of 7 nM. |
| M3244 | Metformin | Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. |
| M5207 | Bempedoic acid (ETC-1002) | Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK. |
| M13811 | ZLN024 hydrochloride | ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively. |
| M13810 | Palmitelaidic Acid | Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue. |
| M13806 | AICAR phosphate | AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. |
| M13805 | 7-Methoxyisoflavone | 7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK). |
| M13407 | YLF-466D | YLF-466Dis a novel AMPK activator that inhibits thrombin - induced platelet aggregation. |
| M13362 | ASP4132 | ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM and anticancer activity that promotes tumor regression in a xenograft mouse model of breast cancer. |
| M13361 | MK8722 | Mk-8722 is a potent, direct, PAN-AMPK allosteric activator. |
| M11462 | IMM-H007 | Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK). |
| M11324 | BC1618 | BC1618, an orally active Fbxo48 inhibitor, stimulates Ampk signaling (preventing activated pAmpkα from being degraded by fBXO48-mediated proteasome). BC1618 promotes mitochondrial division, autophagy and insulin sensitivity in the liver. |
| M11007 | O-304 | O-304 is a pioneering, orally active pan-AMPK activator that increases AMPK activity by inhibiting dephosphorylation of pAMPK. |
| M10948 | MOTS-c(Human) Acetate | MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. |
| M9764 | MK-3903 | MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). |
| M8761 | GSK621 | GSK621 is a specific and potent AMPK activator with an IC50 value of 13-30 μM for AML cell lines. GSK621 can induce autophagy and apoptosis. |
| M6358 | 8-Chloroadenosine | 8-Chloroadenosine is a cytotoxic nucleoside analog; inhibits RNA synthesis. |
| M5549 | Danthron | Danthron functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes. |
| M5336 | Phenformin hydrochloride | Phenformin hydrochloride is the hydrochloride salt of phenformin which is an anti-diabetic agent from the biguanide class. It activates AMPK, increasing activity and phosphorylation. |
| M5326 | HTH-01-015 | HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2. |
| M4575 | Vaccarin | Vaccarin is an active flavonoid glycoside with a variety of biological functions. Vaccarin significantly promoted wound healing and proliferation of endothelial and fibroblast cells at the wound site. Vaccarin improves insulin resistance and steatosis by activating the AMPK signaling pathway. |
| M4483 | Platycodin-D | Platycodin D, a saponin isolated from orange stem, is an activator of AMPKα and has anti-obesity activity. |
| M4449 | Cimigenol-3-O-α-L-arabinoside | Cimiracemoside C, the active ingredient in cohosh, activates AMPK and has anti-diabetes potential. |
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